Effect of Ozone Therapy on Pain and Functional Status in Fibromyalgia Patients.

IF 1.9 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Ozlem Kuculmez
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引用次数: 0

Abstract

Introduction: Fibromyalgia is a musculoskeletal disease that is frequently detected in young women, includes symptoms such as fatigue, sleep disturbances, and cognitive dysfunction unrelated to pain, and negatively affects the patient's quality of daily life. Ozone therapy increases tissue oxygenation, activates antioxidant mechanisms, and may be used in patients with fibromyalgia. The aim of this study is to investigate the efficacy of ozone therapy on pain and functional status in fibromyalgia patients.

Methods: It was a longitudinal cross-sectional study. The study was performed by Baskent University Alanya Hospital. Patients, aged between 20 and 65 years, diagnosed with fibromyalgia according to American College of Rheumatology 2010 criteria and had ozone therapy were included to the study. It was hypothesized that the ozonetherapy increases tissue oxygenization, decreases pain level and supplies better quality of life in patients with fibromyalgia. Demographic and three-month follow-up data of fibromyalgia patients who had received 10 sessions of ozone autohemotherapy were obtained from the hospital database. The patients received 10 sessions of ozone autohemotherapy at a concentration of 25 µg/ml (100 ml of blood and 100 ml of ozone gas) 2-3 times per week. The values of the Visual Analog Score and Fibromyalgia Impairment Questionnaire scores in the three-month follow-up were statistically compared, and P < .05 was considered statistically significant.

Results: 20 female patients were analyzed. The mean age of patients was 54. 8 ± 15. 5 years. Patients' median (min-max) baseline score on Visual Analog Score was 9 (5-10), post-treatment score was 3 (0-8), 3 (1-8) in 1st month, and 4 (1-8) in 3rd month. The median (min-max) Fibromyalgia Impairment Questionnaire score of patients was 73.29 (29.2 - 87.2) at baseline, 31.67 (7.01 - 66.99) after treatment, 24. 6 (10. 7- 63. 3) at 1st month, and 24.67 (10.67- 66.99) 3rd month. A significant decrease in pain (P < .001) and functional improvement (P < .001) was observed in the patients after ozonetherapy.

Conclusion: After 10 sessions of ozonetherapy in fibromyalgia patients, the Visual Analog Score and Fibromyalgia Impairment Questionnaire scores decreased significantly and this well-being persisted for three months. Ozonetherapy may be considered for fibromyalgia treatment protocol as complementary therapy. For determining dosage and session standarts further studies are needed.

臭氧疗法对纤维肌痛患者疼痛和功能状态的影响
导言:纤维肌痛是一种肌肉骨骼疾病,常发于年轻女性,包括疲劳、睡眠障碍和认知功能障碍等与疼痛无关的症状,对患者的日常生活质量造成负面影响。臭氧疗法能增加组织含氧量,激活抗氧化机制,可用于纤维肌痛患者。本研究旨在探讨臭氧疗法对纤维肌痛患者疼痛和功能状态的疗效:这是一项纵向横断面研究。研究由巴斯克特大学阿拉尼亚医院进行。研究对象包括根据美国风湿病学会 2010 年标准确诊为纤维肌痛并接受过臭氧治疗的 20 至 65 岁患者。研究假设臭氧疗法能提高纤维肌痛患者的组织含氧量、减轻疼痛程度并提高生活质量。研究人员从医院数据库中获取了接受过 10 次臭氧自体化学疗法的纤维肌痛患者的人口统计学数据和三个月的随访数据。患者接受了10次臭氧自体化疗,浓度为25微克/毫升(100毫升血液和100毫升臭氧气体),每周2-3次。对随访三个月的视觉模拟评分和纤维肌痛损害问卷评分进行统计比较,P < .05 为差异有统计学意义。患者的平均年龄为 54.8 ± 15.5 岁。患者视觉模拟评分基线中位数(最小-最大)为 9(5-10)分,治疗后评分为 3(0-8)分,第 1 个月为 3(1-8)分,第 3 个月为 4(1-8)分。患者纤维肌痛损害问卷评分的中位数(最小值-最大值)为基线时 73.29(29.2 - 87.2)分,治疗后 31.67(7.01 - 66.99)分,治疗后 24.6(10.7- 63.3),第三个月为 24.67(10.67- 66.99)。臭氧疗法后,患者疼痛明显减轻(P < .001),功能明显改善(P < .001):结论:在对纤维肌痛患者进行 10 次臭氧治疗后,患者的视觉模拟评分和纤维肌痛损害问卷评分明显降低,而且这种改善持续了三个月。在纤维肌痛治疗方案中,可以考虑将臭氧疗法作为辅助疗法。在确定剂量和疗程标准方面,还需要进一步的研究。
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来源期刊
Alternative therapies in health and medicine
Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
0.90
自引率
0.00%
发文量
219
期刊介绍: Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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