High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions

IF 8.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry Pub Date : 2024-10-23 DOI:10.1016/j.ultsonch.2024.107120

Kajal Sharma , Hao Deng , Parikshit Banerjee , Zaimao Peng , Jackson Gum , Alberto Baldelli , Jacek Jasieniak , Laurence Meagher , Mikaël M. Martino , Venkat Gundabala , Tuncay Alan

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Abstract

Water-in-water (w/w) emulsions, comprising aqueous droplets within another continuous aqueous phase, rely on a low interfacial tension for stability. Thus far, it has been challenging to control their size and stability without the use of stabilizers. In this study, we introduce a microfluidic technique that addresses these challenges, producing stable w/w emulsions with precisely controlled size and uniformity. Results shows that using an acoustically actuated microfluidic mixer, PEG, Dextran, and alginate solutions (84.66 mPa.s viscosity difference) were homogenized rapidly, forming uniformly distributed w/w emulsions stabilized in alginate gels.

The emulsion size, uniformity, and shear sensitivity can be tuned by modifying the alginate concentration. Biocompatibility was evaluated by monitoring the viability of kidney cells in the presence of emulsions and gels. In conclusion, this study not only showed emulsion formation with a high mixing efficiency exceeding 90 % for all viscosities, actuated at an optimized frequency of 1.064 MHz, but also demonstrated that an aqueous, solvent, and emulsifier-free composition exhibited remarkable biocompatibility, holding promise for precise drug delivery, cosmetics, and food applications.

Abstract Image

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高精度声流体合成稳定、生物兼容的水包水乳剂

水包水（w/w）乳液由另一个连续水相中的水液滴组成，其稳定性依赖于较低的界面张力。迄今为止，在不使用稳定剂的情况下控制其大小和稳定性一直是一项挑战。在本研究中，我们介绍了一种微流控技术，该技术可以解决这些难题，生产出尺寸和均匀性均可精确控制的稳定的 w/w 乳剂。研究结果表明，使用声学驱动微流控混合器，PEG、葡聚糖和海藻酸溶液（粘度差为 84.66 mPa.s）可快速均质，形成分布均匀、稳定在海藻酸凝胶中的湿重乳剂。通过监测肾细胞在乳剂和凝胶存在下的存活率，对生物相容性进行了评估。总之，这项研究不仅显示了在 1.064 MHz 的优化频率下，所有粘度的乳液形成具有超过 90% 的高混合效率，而且还证明了不含水、溶剂和乳化剂的组合物具有显著的生物相容性，有望用于精确给药、化妆品和食品应用。

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来源期刊

Ultrasonics Sonochemistry 化学-化学综合

CiteScore

15.80

自引率

11.90%

发文量

361

审稿时长

59 days

期刊介绍： Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.