The Effects of Two Kinds of Gargles on Oral Mucositis in Patients After Allogeneic Stem Cell Transplantation.

Transplantation proceedings Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI:10.1016/j.transproceed.2024.10.023
Wei Hu, Hua Jiang, Ting Wang, Xiu-Juan Guo, Bei-Bei Zhang, Yan Song, Ce Shi, Xiao-Dong Xu, Lin-Nan Wang, Xin-Xin He, Bo-Ning Liu, Jun-Xiu Zhou, Ze-Yu Xue
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Abstract

Objective: The objective of this study was to compare the effects of two kinds of gargles (Koushu & Koutai) on oral mucositis (OM) in patients with agranulocytosis.

Methods: One hundred eighty patients who underwent allogeneic hematopoietic stem cell transplantation in the Peking University Institute of Hematology were enrolled from March 2018 to January 2019. The subjects were randomly divided into two groups by random number table. The observation group gargled with Koushu gargle, whereas the control group gargled with Koutai gargle. Patients in both groups used 10 to 15 mL of gargles for 2 minutes when awake in the morning, 30 minutes after each meal, and before sleep. The two groups used the same way to gargle except the types of gargle used. The difference of incidence, grade, healing time, and pain grade of oral mucositis were analyzed.

Results: The incidence of oral mucositis in the observation group was significantly lower than that in the control group (P < .01).There were no significant difference in grade of OM, healing time, or pain grade between the two groups (P > .05). The effect of the Koushu gargle on the prevention of OM among the patients with agranulocytosis is better than that of the Koutai gargle. The Koushu gargle is better suited than the Koutai gargle as a prevention and treatment option for the patients.

两种漱口水对异体干细胞移植后患者口腔黏膜炎的影响
研究目的本研究旨在比较两种漱口水(口舒和口泰)对粒细胞减少症患者口腔黏膜炎(OM)的影响:入选2018年3月至2019年1月在北京大学血液病研究所接受异基因造血干细胞移植的180例患者。受试者按随机数字表随机分为两组。观察组使用光舒漱口水漱口,对照组使用光泰漱口水漱口。两组患者均使用 10 至 15 毫升的漱口水,分别在清晨清醒时、餐后 30 分钟和睡前漱口 2 分钟。除漱口水的种类外,两组患者的漱口方式相同。分析两组口腔黏膜炎发病率、等级、愈合时间和疼痛等级的差异:结果:观察组口腔黏膜炎的发生率明显低于对照组(P < .01),两组口腔黏膜炎的等级、愈合时间和疼痛等级无明显差异(P > .05)。在预防粒细胞减少症患者 OM 方面,Koushu 漱口水的效果优于 Koutai 漱口水。作为一种预防和治疗方案,Koushu 漱口水比 Koutai 漱口水更适合患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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