An Update on Clinically Evaluated Medicinal Plants for Psoriasis Management.

Ramin Ansari, Mahkameh Moradi Mehrabadi, Mahnaz Sadat Hosseini, Mehdi Ghahartars, Mohammad Mehdi Zarshenas
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Abstract

Psoriasis is a prevalent inflammatory disease affecting almost 0.5-5 % of the world population. Multiple treatment approaches have been developed to manage psoriasis so far. Although concerns exist in the long-term usage of conventional and biological agents in terms of safety, effectiveness, expensiveness, and tolerability, complementary and alternative medicine (CAM) is a promising point of view for future psoriasis management. In this study, databases including Scopus, PubMed, Google Scholar, and Web of Science were searched for relevant literature on herbal medications clinically evaluated for psoriasis, especially those originating from traditional medicine. About 40 relevant papers were selected by March 2023. Most of the studies were clinical trials on poly-herbal formulations from traditional Chinese medicine (TCM). There are controversial results regarding the efficacy of these herbal formulations in psoriasis mainly due to the variation in the study design. Moreover, the probable protective mechanisms and responsible herbal metabolites of these formulations are summarized. There is a global need for more in-vitro and in-vivo studies based on the standard protocols in terms of the evaluation of the safety and efficacy of topical/ systemic herbal preparations for psoriasis.

经临床评估可用于治疗牛皮癣的药用植物的最新进展。
银屑病是一种常见的炎症性疾病,影响着全球近 0.5%-5% 的人口。迄今为止,已开发出多种治疗银屑病的方法。虽然长期使用传统药物和生物制剂在安全性、有效性、经济性和耐受性方面存在问题,但补充和替代医学(CAM)是未来治疗银屑病的一个有前途的观点。本研究在 Scopus、PubMed、Google Scholar 和 Web of Science 等数据库中搜索了对银屑病进行临床评估的草药相关文献,尤其是源自传统医学的草药。截至 2023 年 3 月,共筛选出约 40 篇相关论文。大多数研究都是关于传统中药多草药配方的临床试验。这些中草药配方对银屑病的疗效存在争议,主要原因是研究设计不同。此外,还总结了这些配方的可能保护机制和主要草药代谢物。在评估银屑病外用/内服草药制剂的安全性和疗效方面,全球需要根据标准方案开展更多的体外和体内研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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