Investigating trends in antibiotic resistance of Escherichia coli isolated from clinical urine specimens in the Orkney Islands.

IF 2.6 4区 生物学 Q3 MICROBIOLOGY
Lily Corse, Allison Cartwright
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引用次数: 0

Abstract

Urinary tract infections (UTIs) are extremely common, affecting people of all ages and health statuses. Although UTIs do not usually cause severe illness, in some cases they can lead to more serious complications, especially if their initial treatment is ineffective due to antimicrobial resistance (AMR). AMR is an increasing issue, exacerbated by misdiagnosis and inappropriate prescribing of antibiotics, thus facilitating further resistance. The aim of this study was to investigate the rates of AMR in Escherichia coli isolated from clinical urine specimens tested at the Balfour Hospital, Orkney, and determine trends related to patient risk factors. Antibiotic susceptibilities were tested for 100 isolates of uropathogenic E. coli using the VITEK 2 Compact (bioMérieux), and data were analysed using percentage resistance rates. Resistance rates were compared by patient sex, age and source (hospital versus community). The findings showed higher AMR in males compared with females, particularly for trimethoprim (TMP), with 52% in males and only 12% in females. AMR tended to be higher in E. coli isolated from hospital inpatients than from community specimens, except for amoxicillin (AMX) and co-amoxiclav. Finally, the study found that AMR of E. coli isolates was greater in patients aged over 50 than 18-50 years old, particularly for AMX and TMP. The highest resistance rates across all patient demographics were for AMX, implying that the use of this antibiotic for the treatment of E. coli UTIs is not appropriate.

调查从奥克尼群岛临床尿液标本中分离出的大肠埃希菌的抗生素耐药性趋势。
尿路感染(UTI)极为常见,影响着各个年龄段和健康状况的人群。虽然尿路感染通常不会引起严重的疾病,但在某些情况下,尿路感染可能会导致更严重的并发症,尤其是在抗菌药耐药性(AMR)导致最初治疗无效的情况下。AMR是一个日益严重的问题,误诊和抗生素处方不当加剧了这一问题,从而进一步助长了抗药性。本研究旨在调查从奥克尼贝尔福医院检测的临床尿液标本中分离出的大肠埃希菌的耐药性发生率,并确定与患者风险因素相关的趋势。使用 VITEK 2 Compact(生物梅里埃)检测了 100 株尿路致病性大肠杆菌分离物的抗生素敏感性,并使用耐药率百分比对数据进行了分析。耐药率按患者性别、年龄和来源(医院与社区)进行了比较。研究结果表明,男性的耐药率高于女性,尤其是对三甲氧苄啶(TMP),男性的耐药率为 52%,而女性仅为 12%。除阿莫西林(AMX)和联合阿莫西林(coamoxiclav)外,从医院住院病人身上分离出的大肠杆菌的AMR往往高于从社区样本中分离出的大肠杆菌。最后,研究发现,50 岁以上患者的大肠埃希菌分离物耐药性高于 18-50 岁患者,尤其是对 AMX 和 TMP。在所有患者人口统计学特征中,AMX 的耐药率最高,这意味着使用这种抗生素治疗大肠杆菌性尿道炎并不合适。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbiology-Sgm
Microbiology-Sgm 生物-微生物学
CiteScore
4.60
自引率
7.10%
发文量
132
审稿时长
3.0 months
期刊介绍: We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms. Topics include but are not limited to: Antimicrobials and antimicrobial resistance Bacteriology and parasitology Biochemistry and biophysics Biofilms and biological systems Biotechnology and bioremediation Cell biology and signalling Chemical biology Cross-disciplinary work Ecology and environmental microbiology Food microbiology Genetics Host–microbe interactions Microbial methods and techniques Microscopy and imaging Omics, including genomics, proteomics and metabolomics Physiology and metabolism Systems biology and synthetic biology The microbiome.
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