Association between a lower T-CD4+ /CD8+ lymphocyte ratio and cognitive impairment in older persons with HIV.

IF 3.5 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Carlos Alberto Ruiz-Manríquez, José Alberto Avila-Funes, Fátima Brañas, Brenda Crabtree-Ramírez, Hélène Amieva, Virgilio Hernández-Ruiz
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引用次数: 0

Abstract

Purpose: To ascertain the association between the LT-CD4 + /CD8 + ratio and cognitive impairment in older people living with HIV.

Methods: A cross-sectional study was conducted, including 207 adults aged > 50 years with HIV, receiving care at a tertiary-care hospital in Mexico City. Participants underwent a standardized geriatric and neuropsychological assessment to establish the presence of HIV-associated neurocognitive disorder according to the validated Antinori criteria. Multivariate logistic regression models were performed to determine the association between T-CD4 + /CD8 + lymphocyte ratio tercile values (0.57-0.91, and < 0.56; with > 0.91 being the reference category) and cognitive impairment.

Results: Participants' median age was 56 (IQR 53-62) years and 173 (83.6%) were men. The prevalence of any kind of cognitive impairment according to the Antinori criteria was 66.2% (n = 137), the highest proportion being asymptomatic neurocognitive impairment (n = 114, 83.2%). Adjusted logistic regression analyses showed that the lowest LT-CD4 + /CD8 + ratio tercile values (< 0.56) were independently associated with the presence of cognitive impairment (OR 3.16; 95% CI 1.22-8.16, p = 0.017).

Conclusion: Lower LT-CD4 + /CD8 + ratios are independently associated with cognitively impaired older persons with HIV, which represents another factor that could be addressed to identify individuals at risk and focus on cognitive screening as well as correction of other modifiable risk factors.

感染艾滋病毒的老年人中较低的 T-CD4+ /CD8+ 淋巴细胞比率与认知障碍之间的关系。
目的:确定感染艾滋病毒的老年人中LT-CD4 + /CD8 +比率与认知障碍之间的关系:研究对象包括 207 名年龄大于 50 岁、在墨西哥城一家三级医院接受治疗的艾滋病病毒感染者。参与者接受了标准化的老年医学和神经心理学评估,以根据有效的安东尼标准确定是否存在艾滋病相关神经认知障碍。通过多变量逻辑回归模型确定 T-CD4 + /CD8 + 淋巴细胞比值三元组(0.57-0.91,0.91 为参考值)与认知障碍之间的关系:参与者的中位年龄为 56(IQR 53-62)岁,173 人(83.6%)为男性。根据安东尼标准,任何一种认知障碍的患病率为 66.2%(n = 137),其中无症状神经认知障碍的患病率最高(n = 114,83.2%)。调整后的逻辑回归分析显示,LT-CD4 + /CD8 + 比率三元组值最低(结论:LT-CD4 + /CD8 + 比率三元组值越低(结论:LT-CD4 + /CD8 + 比率三元组值越低):较低的LT-CD4 + /CD8 +比率与感染艾滋病毒的老年人认知功能受损独立相关,这是另一个可用于识别高危人群的因素,重点在于认知筛查以及纠正其他可改变的风险因素。
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来源期刊
European Geriatric Medicine
European Geriatric Medicine GERIATRICS & GERONTOLOGY-
CiteScore
6.70
自引率
2.60%
发文量
114
审稿时长
6-12 weeks
期刊介绍: European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine. The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.
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