Identification of Key miRNAs in Endometriosis.

Francesca Blandino, Saviana Antonella Barbati, Luca Forlani, Giulia Coppola, Noemi Meschino, Ilde Cecchinelli, Antonietta Cosco Mazzuca, Valentina Veltri, Riccardo Giannico, Graziella Calugi
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Abstract

Introduction: Endometriosis, a prevalent gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, poses significant challenges in diagnosis and management due to its unclear pathogenesis and lack of specific biomarkers.

Objective: This study investigates the potential use of microRNAs (miRNAs) as key markers in endometriosis by studying two cohorts of patients (14 patients diagnosed with endometriosis and 15 patients with gynecological benign lesions, different from endometriosis).

Methods: MicroRNA sequencing analysis was tested within data management by a custom pipeline designed by Eurofins Genoma Group.

Results: We identified a specific miRNA expression profile associated with endometriosis to feature specific disease molecular clusters to further elucidate the underlying mechanisms driving endometriosis pathogenesis. Data from the present study suggest a specific miRNA scar for endometriosis compared to other gynecological diseases to develop screening tools in early diagnosis and to ameliorate the management of the disease itself.

Conclusion: This study lays the foundation for the identification of key miRNAs involved in the disease pathogenesis to unveil the molecular signatures in the complex scenario of endometriosis. Further validation and exploration of these findings are needed to develop tools to improve molecular diagnosis and to create a machine-learning prediction algorithm in the future.

鉴定子宫内膜异位症的关键 miRNA。
导言:子宫内膜异位症是一种常见的妇科疾病,其特征是子宫腔外存在子宫内膜样组织,由于其发病机制不明确且缺乏特异性生物标志物,因此给诊断和治疗带来了巨大挑战:本研究通过对两组患者(14 名确诊为子宫内膜异位症的患者和 15 名患有妇科良性病变(不同于子宫内膜异位症)的患者)的研究,探讨了微RNA(miRNA)作为子宫内膜异位症关键标志物的潜在用途:方法:在Eurofins Genoma集团设计的定制流水线数据管理中测试了microRNA测序分析:结果:我们确定了与子宫内膜异位症相关的特定 miRNA 表达谱,以特定疾病分子群为特征,进一步阐明了子宫内膜异位症发病机制的内在驱动机制。本研究的数据表明,与其他妇科疾病相比,子宫内膜异位症有一个特定的 miRNA 瘢痕,可用于开发早期诊断的筛查工具,并改善疾病本身的治疗:本研究为鉴定参与疾病发病机制的关键 miRNAs 奠定了基础,从而揭示了子宫内膜异位症复杂情况下的分子特征。需要对这些发现进行进一步验证和探索,以开发改进分子诊断的工具,并在未来创建机器学习预测算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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