[Clinical Analysis of CD4⁺CD8^- T-Cell Large Granular Lymphocytic[JP] Leukemia].

Q4 Medicine

中国实验血液学杂志 Pub Date : 2024-10-01 DOI:10.19746/j.cnki.issn.1009-2137.2024.05.013

Xiang-Xiang Chang, Shang-Biao Sun, Yu-Wen Li, Miao Wang, Yan-Qing Zhu

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Abstract

Objective: To investigate the clinical characteristics and treatment of patients with CD4⁺CD8^- T-cell large granular lymphocytic leukemia (T-LGLL).

Methods: The clinical manifestations, diagnosis and treatment of 1 case of CD4⁺CD8^- T-LGLL patient were reported, and relevant literatures were reviewed.

Results: The patient was a 70-year-old woman with slow clinical progress, mainly manifested by thrombocytopenia and myelodysplasia. The blood smear was mainly composed of large granular lymphocytes. Immunotyping and T-cell receptor gene rearrangement analysis showed that it was in line with T-LGLL. Partial remission(PR) was achieved through the treatment of cyclophosphamide(50 mg/d) combined with prednisone(gradually reduced and stopped later).

Conclusion: CD4⁺CD8^- T-LGLL is very rare in clinical practice, and its clinical manifestations are different from those of CD4^-CD8⁺ T-LGLL.

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[CD4+CD8-T细胞大颗粒淋巴细胞[JP]白血病临床分析]。

目的研究CD4+CD8-T细胞大颗粒淋巴细胞白血病（T-LGLL）患者的临床特征和治疗方法：方法：报告1例CD4+CD8- T-LGLL患者的临床表现、诊断和治疗，并回顾相关文献：患者为一名 70 岁女性，临床进展缓慢，主要表现为血小板减少和骨髓增生异常。血涂片主要由大颗粒淋巴细胞组成。免疫分型和T细胞受体基因重排分析表明，该患者符合T-LGLL。通过环磷酰胺（50 毫克/天）联合泼尼松（逐渐减量，随后停药）治疗，患者病情得到部分缓解（PR）：结论：CD4+CD8- T-LGLL 在临床上非常罕见，其临床表现与 CD4-CD8+ T-LGLL 不同。

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