Clinical characteristics of chronic obstructive pulmonary disease according to smoking status.

IF 2.5 Q2 RESPIRATORY SYSTEM
Joo Hun Park
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引用次数: 0

Abstract

COPD can be caused by various factors, including lung infections, asthma, air pollution, childhood growth disorders, and genetic factors, although smoking is a predominant risk factor. The main pathological mechanisms in COPD involve small airway disease, emphysema, mucus hypersecretion, and vascular disorders. COPD in non-smokers is characterized by normal FEV1 decline, equal distribution of sex, younger age of onset, fewer comorbidities, milder airflow obstruction, normal diffusing capacity of the lungs for carbon monoxide (DLCO) and radiological features such as more air-trapping and less severe emphysema, compared to COPD in smokers. COPD in non-smokers is still accompanied by a high prevalence of acute exacerbation almost equal to COPD in smokers. Moreover, COPD per se is an independent risk factor for the development of lung cancer, irrespective of smoking status. Considering that COPD coexists with numerous comorbidities, effective management of these comorbidities is essential, and multifaceted efforts are required for the comprehensive treatment of COPD.

根据吸烟状况确定慢性阻塞性肺病的临床特征。
慢性阻塞性肺病可由多种因素引起,包括肺部感染、哮喘、空气污染、儿童生长障碍和遗传因素,但吸烟是主要的危险因素。慢性阻塞性肺病的主要病理机制包括小气道疾病、肺气肿、粘液分泌过多和血管病变。与吸烟者的慢性阻塞性肺病相比,非吸烟者的慢性阻塞性肺病具有以下特点:FEV1 下降正常、性别分布均匀、发病年龄较小、合并症较少、气流阻塞较轻、肺部对一氧化碳的弥散能力(DLCO)正常,以及更多的空气截留和较轻的肺气肿等放射学特征。非吸烟者慢性阻塞性肺病的急性加重率仍然很高,几乎与吸烟者的慢性阻塞性肺病相同。此外,无论吸烟与否,慢性阻塞性肺病本身就是罹患肺癌的独立风险因素。考虑到慢性阻塞性肺病与多种并发症并存,有效治疗这些并发症至关重要,需要多方面的努力来综合治疗慢性阻塞性肺病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.30
自引率
0.00%
发文量
42
审稿时长
12 weeks
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