Production and characterization of Zn- and Cu-doped Y2O3-Al2O3-SiO2 (YAS) glass microspheres.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Turkish Journal of Medical Sciences Pub Date : 2024-09-08 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5888

Fatma Ünal, Batur Ercan

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引用次数: 0

Abstract

Background/aim: Y₂O₃-Al₂O₃-SiO₂ (YAS) glass microspheres are currently used in radioembolization treatment. However, abscess formation can occur following this treatment. This study aims to endow YAS glass microspheres with antibacterial properties to address the abscesses forming in patients after radioembolization treatment.

Materials and methods: In this study, undoped YAS glass microspheres and those doped with antibacterial agents zinc (Zn) and/or copper (Cu) were successfully fabricated using a sol-gel derived method.

Results: After heat treatment, the microspheres exhibited an amorphous structure. Additionally, the incorporation of Zn and/or Cu dopants did not alter the patterns observed in the X-ray diffraction analysis. Fourier transform infrared spectroscopy analysis detected Si-O-Si, Al-O-Al, and Y-O band vibrations within the structure. The presence of Zn and Cu dopants was confirmed through X-ray photoelectron spectroscopy analysis. Scanning electron microscopy revealed that all samples possessed a regular microsphere morphology, with average particle sizes ranging from 6 to 50 μm. These average particle sizes were further confirmed using a mastersizer.

Conclusion: The antibacterial agent-doped YAS glass microspheres show promise in combating infections that occur following radioembolization treatment.

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掺杂锌和铜的 Y2O3-Al2O3-SiO2 (YAS) 玻璃微球的制备和表征。

背景/目的：Y2O3-Al2O3-SiO2（YAS）玻璃微球目前用于放射栓塞治疗。然而，这种治疗方法可能会形成脓肿。本研究旨在赋予 YAS 玻璃微球抗菌特性，以解决放射性栓塞治疗后患者形成脓肿的问题：本研究采用溶胶-凝胶衍生法成功制备了未掺杂的 YAS 玻璃微球和掺杂抗菌剂锌（Zn）和/或铜（Cu）的微球：结果：经过热处理后，微球呈现出无定形结构。此外，锌和/或铜掺杂剂的加入并没有改变 X 射线衍射分析中观察到的图案。傅立叶变换红外光谱分析检测到了结构中的 Si-O-Si、Al-O-Al 和 Y-O 带振动。X 射线光电子能谱分析证实了锌和铜掺杂物的存在。扫描电子显微镜显示，所有样品都具有规则的微球形态，平均粒径为 6 至 50 μm。结论：掺入抗菌剂的微球样品具有良好的抗菌性能：结论：掺入抗菌剂的 YAS 玻璃微球在抗击放射性栓塞治疗后出现的感染方面大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Medical Sciences 医学-医学：内科

CiteScore

4.60

自引率

4.30%

发文量

143

审稿时长

3-8 weeks

期刊介绍： Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical details of a given medical subspeciality may not be evaluated for publication.