Production and characterization of Zn- and Cu-doped Y2O3-Al2O3-SiO2 (YAS) glass microspheres.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-08 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5888

Fatma Ünal, Batur Ercan

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引用次数: 0

Abstract

Background/aim: Y₂O₃-Al₂O₃-SiO₂ (YAS) glass microspheres are currently used in radioembolization treatment. However, abscess formation can occur following this treatment. This study aims to endow YAS glass microspheres with antibacterial properties to address the abscesses forming in patients after radioembolization treatment.

Materials and methods: In this study, undoped YAS glass microspheres and those doped with antibacterial agents zinc (Zn) and/or copper (Cu) were successfully fabricated using a sol-gel derived method.

Results: After heat treatment, the microspheres exhibited an amorphous structure. Additionally, the incorporation of Zn and/or Cu dopants did not alter the patterns observed in the X-ray diffraction analysis. Fourier transform infrared spectroscopy analysis detected Si-O-Si, Al-O-Al, and Y-O band vibrations within the structure. The presence of Zn and Cu dopants was confirmed through X-ray photoelectron spectroscopy analysis. Scanning electron microscopy revealed that all samples possessed a regular microsphere morphology, with average particle sizes ranging from 6 to 50 μm. These average particle sizes were further confirmed using a mastersizer.

Conclusion: The antibacterial agent-doped YAS glass microspheres show promise in combating infections that occur following radioembolization treatment.

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掺杂锌和铜的 Y2O3-Al2O3-SiO2 (YAS) 玻璃微球的制备和表征。

背景/目的：Y2O3-Al2O3-SiO2（YAS）玻璃微球目前用于放射栓塞治疗。然而，这种治疗方法可能会形成脓肿。本研究旨在赋予 YAS 玻璃微球抗菌特性，以解决放射性栓塞治疗后患者形成脓肿的问题：本研究采用溶胶-凝胶衍生法成功制备了未掺杂的 YAS 玻璃微球和掺杂抗菌剂锌（Zn）和/或铜（Cu）的微球：结果：经过热处理后，微球呈现出无定形结构。此外，锌和/或铜掺杂剂的加入并没有改变 X 射线衍射分析中观察到的图案。傅立叶变换红外光谱分析检测到了结构中的 Si-O-Si、Al-O-Al 和 Y-O 带振动。X 射线光电子能谱分析证实了锌和铜掺杂物的存在。扫描电子显微镜显示，所有样品都具有规则的微球形态，平均粒径为 6 至 50 μm。结论：掺入抗菌剂的微球样品具有良好的抗菌性能：结论：掺入抗菌剂的 YAS 玻璃微球在抗击放射性栓塞治疗后出现的感染方面大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.