Nationwide study on the prevalence of rheumatoid factor and anticitrullinated peptide positivity and their contribution to rheumatoid arthritis diagnosis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5872

Hasan Satiş, Abdulsamet Erden, Emre Bilgin, Gizem Ayan, Berkan Armağan, Duygu Tecer, Alper Sari, Umut Kalyoncu, Murat Çağlayan, Mustafa Mahir Ülgü, Mustafa Okan Ayvali, Naim Ata, Şuayip Birinci

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引用次数: 0

Abstract

Background/aim: Rheumatoid factor (RF) and anticitrullinated peptide (anti-CCP) are specific for rheumatoid arthritis (RA) diagnosis. However, they could be positive in other diseases and even in healthy populations. The aim was to investigate the prevalence of positive RF and anti-CCP antibodies in persons admitted to hospital for any reason and on a national scale.

Materials and methods: The National Electronic Health Database, which contains the clinical records of over 80 million people, was used to design this multicenter, retrospective cohort study. The subjects included in the study were divided into age groups according to 10-year periods. RA cases were identified using ICD-10 codes that included M05, M06, M08, and their subgroups. RF and anti-CCP positivity were evaluated in terms of their contribution to the risk of being diagnosed with RA, with the change according to age and sex.

Results: During the 1.1.2018-31.12.2021 period, 13,918,072 RF tests were performed in 11,849,440 people, whereas 1,183,607 anti-CCP tests were performed in 1,020,967 people. Moreover, 797,089 people had both tests performed at least once. The RF positivity rate in patients who only requested RF tests was 14.72% and it was 35.04% for anti-CCP positivity in those who only requested anti-CCP tests. The rate of concomitant RF and anti-CCP positivity was 22.56%. An RA diagnosis was made in 27.8% of RF-positive people, 39.73% of anti-CCP-positive people, and 56.6% of co-RF and anti-CCP-positive people. RF positivity and concomitant RF and anti-CCP positivity increased with age and were more common in females.

Conclusion: RF and anti-CCP positivity may be seen in a healthy population with female predominance. As age increases, the risk of RF positivity rises, but anti-CCP positivity does not change. Concomitant RF and anti-CCP positivity shows the highest risk of RA development with respect to either antibody positivity alone.

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关于类风湿因子和抗瓜氨酸肽阳性率及其对类风湿关节炎诊断的贡献的全国性研究。

背景/目的：类风湿因子（RF）和抗瓜氨酸肽（anti-CCP）是诊断类风湿性关节炎（RA）的特异性指标。然而，它们在其他疾病甚至健康人群中也可能呈阳性。该研究旨在调查全国范围内因任何原因入院者的 RF 和抗CCP 抗体阳性率：这项多中心、回顾性队列研究使用了包含 8000 多万人临床记录的国家电子健康数据库。研究对象按 10 年划分为不同年龄组。使用ICD-10编码（包括M05、M06、M08及其亚组）确定RA病例。评估了RF和抗CCP阳性对被诊断为RA风险的贡献，以及根据年龄和性别的变化：在2018年1月1日至2021年12月31日期间，对11849440人进行了13918072次RF检测，对1020967人进行了1183607次抗CCP检测。此外，有 797 089 人至少进行过一次这两种检测。在只要求进行射频检测的患者中，射频阳性率为 14.72%，而在只要求进行抗凝血酶检测的患者中，抗凝血酶阳性率为 35.04%。RF和抗CCP同时阳性的比例为22.56%。RF阳性者中有27.8%被诊断为RA，抗CCP阳性者中有39.73%被诊断为RA，RF和抗CCP同时阳性者中有56.6%被诊断为RA。RF阳性以及同时RF和抗CCP阳性随年龄增长而增加，女性更为常见：RF和抗CCP阳性可能出现在健康人群中，女性居多。随着年龄的增长，RF 阳性的风险会增加，但抗CCP 阳性的风险不会改变。RF和抗CCP同时阳性与单独两种抗体阳性相比，RA的发病风险最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.