Ultrasound-mediated cardiovascular thrombolysis: from Sonothrombolysis to Sonoperfusion.

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Postgraduate Medical Journal Pub Date : 2024-10-31 DOI:10.1093/postmj/qgae127

Zhixin Jiang, Nan Jiang, Zhiwen Wang, Qing Deng, Qing Zhou, Bo Hu

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引用次数: 0

Abstract

The incidence of coronary artery disease has been increasing in recent years, with acute myocardial infarction as its most severe onset. The major aim for clinical treatment is to restore myocardial blood supply with the recanalization of coronary circulation as early as possible, while the still existed issue of microcirculation thromboembolism has become a serious obstacle. Thus, thrombus elimination in coronary microcirculation is crucial and essential to improve the treatment outcome of acute myocardial infarction. In recent years, from sonothrombolysis to sonoperfusion, ultrasound-mediated cardiovascular thrombolysis can effectively solve the problem of vascular thromboembolism, including microcirculation thromboembolism, and the treatment method is expected to obtain satisfied thrombolytic treatment effect with microthrombus elimination in coronary microvessels and function recovery of terminal microcirculation, which has potential clinical value for the establishment of novel treatment for coronary thromboembolism. Therefore, this paper reviews ultrasound-mediated cardiovascular thrombolysis including sonothrombolysis and sonoperfusion for the application exploration in the treatment of coronary artery thromboembolism, the mechanism of action, and its research progress.

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超声介导的心血管溶栓：从超声溶栓到超声灌注。

近年来，冠心病的发病率呈上升趋势，其中以急性心肌梗死发病最为严重。临床治疗的主要目的是尽早再通冠状动脉循环，恢复心肌供血，而目前仍然存在的微循环血栓栓塞问题已成为严重障碍。因此，消除冠状动脉微循环中的血栓对改善急性心肌梗死的治疗效果至关重要。近年来，从超声溶栓到超声灌注，超声介导的心血管溶栓治疗可有效解决包括微循环血栓栓塞在内的血管血栓栓塞问题，该治疗方法有望在冠状动脉微血管微血栓消除和末端微循环功能恢复的同时获得满意的溶栓治疗效果，对建立冠状动脉血栓栓塞的新型治疗方法具有潜在的临床价值。因此，本文综述了超声介导的心血管溶栓（包括超声溶栓和超声灌注）在冠状动脉血栓栓塞治疗中的应用探索、作用机制及其研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medical Journal 医学-医学：内科

CiteScore

8.50

自引率

2.00%

发文量

131

审稿时长

2.5 months

期刊介绍： Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.