Effects of Ginseng on Cognitive Function: A Systematic Review and Meta-Analysis.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Maogui Zeng, Kuan Zhang, Juan Yang, Yu Zhang, Pengcheng You, Lin Yan, Yiling Weng
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Abstract

Ginseng is a kind of traditional Chinese medicine. It is widely believed that ginseng can improve cognitive function, but its clinical efficacy is still controversial. This study aimed to systematically evaluate the effects of ginseng on cognitive function improvement. This is a systematic review and meta-analysis of the randomized controlled trials (RCTs). Searching PubMed, Web of Science, the Cochrane Library, and Medline databases to collect RCTs of ginseng on the effects of human cognitive function. The time range is from the establishment of the database to December 2023. The main intervention in the trials was ginseng preparation. The Cochrane risk-of-bias tool 2.0 (RoB2.0) and Jadad scale were used to assess the risk of bias and evaluate the quality of the included articles. After data extraction, meta-analysis was performed using Stata 17.0 software. A total of 15 RCTs were included, and 671 patients were analyzed. The subjects included healthy people, patients of cognitive impairment, schizophrenia, hospitalized, and Alzheimer's disease. The intervention measures were mainly ginseng preparations. The meta-analysis results indicated that ginseng has a significant effect on memory improvement (SMD = 0.19, 95%CI: 0.02-0.36, p < 0.05), especially at high doses (SMD = 0.33, 95%CI: 0.04-0.61, p < 0.05). Ginseng did not have a positive effect on overall cognition, attention, and executive function (SMD = 0.06, 95%CI: -0.64-0.77, p = 0.86; SMD = 0.06, 95%CI: -0.12 to 0.23, p = 0.54; SMD = -0.03, 95%CI: -0.28 to 0.21, p = 0.79). Ginseng has some positive effects on cognitive improvement, especially on memory improvement. But in the future, more high-quality studies are needed to determine the effects of ginseng on cognitive function. Trial Registration: Prospero: CRD42024514231.

人参对认知功能的影响:系统回顾与元分析》。
人参是一种传统中药。人们普遍认为人参能改善认知功能,但其临床疗效仍存在争议。本研究旨在系统评估人参对改善认知功能的作用。本研究对随机对照试验(RCTs)进行了系统回顾和荟萃分析。检索 PubMed、Web of Science、Cochrane Library 和 Medline 数据库,收集人参对人类认知功能影响的 RCTs。时间范围为数据库建立至 2023 年 12 月。试验的主要干预措施是人参制剂。采用 Cochrane 偏倚风险工具 2.0(RoB2.0)和 Jadad 量表评估偏倚风险,并评价纳入文章的质量。数据提取后,使用 Stata 17.0 软件进行了荟萃分析。共纳入 15 篇研究性临床试验,分析了 671 名患者。研究对象包括健康人、认知障碍患者、精神分裂症患者、住院患者和阿尔茨海默病患者。干预措施主要是人参制剂。荟萃分析结果表明,人参对改善记忆力有显著效果(SMD = 0.19,95%CI:0.02-0.36,p
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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