Examining the effect of salbutamol use in ozone air pollution by people with exercise-induced bronchoconstriction.

IF 2.2 Q3 PHYSIOLOGY
Bennett T Stothers, Andy Hung, Patric E O Gonçalves, Lulu X Pei, Tessa van de Kerkhof, Jem I Arnold, Owen D Harris, Nadine Borduas-Dedekind, Andrew W Sheel, Michael S Koehle
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Abstract

Previous studies based on animal models have raised concerns about salbutamol use in ozone air pollution with regard to ozone related lung injury. We conducted a double-blind, randomized, placebo-controlled crossover study including 18 subjects diagnosed with EIB by a eucapnic voluntary hyperpnea (EVH) test. Participants completed 30 min of standardized moderate to vigorous exercise in four conditions: ozone plus salbutamol; room air plus salbutamol; ozone plus placebo medication; and room air plus placebo medication. Spirometry, fraction of exhaled nitric oxide, and symptoms were measured before, immediately after, 30 min after and 1 h after exercise. Measurements between the four conditions were compared using percent change from pre to post exercise. There was a statistically significant difference between the salbutamol and placebo medication groups for spirometric variables including FEV1 (Estimate = 6.3, 95% CI: 4.23-8.37, p < 0.001). No differences were observed between ozone and room air exposures. There were no significant differences in FeNO response between experimental conditions. We found that salbutamol improved pulmonary function in individuals with EIB when exercising in ozone and did not increase eosinophilic airway inflammation as indicated by FeNO. This evidence suggests that it is safe for people with EIB to continue to use salbutamol as proscribed when ozone levels are elevated.

研究运动诱发支气管收缩患者在臭氧空气污染中使用沙丁胺醇的效果。
以往基于动物模型的研究对在臭氧空气污染中使用沙丁胺醇会造成臭氧相关肺损伤表示担忧。我们进行了一项双盲、随机、安慰剂对照交叉研究,研究对象包括 18 名通过优卡自愿过度呼吸测试(EVH)确诊为 EIB 的受试者。受试者在四种条件下完成了30分钟的标准化中度至剧烈运动:臭氧加沙丁胺醇;室内空气加沙丁胺醇;臭氧加安慰剂药物;室内空气加安慰剂药物。分别在运动前、运动后、运动后 30 分钟和运动后 1 小时测量肺活量、呼出一氧化氮的比例和症状。使用从运动前到运动后的百分比变化来比较四种情况下的测量结果。沙丁胺醇组和安慰剂组在肺活量测量变量方面有显著的统计学差异,包括 FEV1(估计值 = 6.3,95% CI:4.23-8.37,P<0.05)和 FEV1(估计值 = 6.3,95% CI:4.23-8.37,P<0.05)。
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来源期刊
Physiological Reports
Physiological Reports PHYSIOLOGY-
CiteScore
4.20
自引率
4.00%
发文量
374
审稿时长
9 weeks
期刊介绍: Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.
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