Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.1515/med-2024-1053

Yunlong Pei, Haixiao Jiang, Enpeng Zhang, Boming Xia, Lun Dong, Yan Dai

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引用次数: 0

Abstract

Temporal muscle thickness (TMT) serves as an indicator of sarcopenia and holds predictive value for various cancers. This study aims to evaluate the prognostic significance of TMT for high-grade glioma patients. A retrospective review of 172 high-grade glioma patients from January 2015 to December 2022 was conducted. TMT value was measured based on contrast-enhanced T1-weighted magnetic resonance images before surgery. Pearson analysis was used to evaluate potential correlations. Cox regression analysis was performed to evaluate overall survival for high-grade glioma patients. In our study, the cutoff value of TMT was determined as 7.4 mm. TMT value was not a significant prognostic predictor for high-grade glioma patients (hazard ratio [HR]: 1.151, 95% confidence interval [CI]: 0.9299-1.424, p = 0.196). World Health Organization (WHO) VI and high body mass index (BMI) value were significantly associated with poorer survival outcomes (HR: 2.6689, 95% CI: 1.5729-4.528, p < 0.001; HR: 1.120, 95% CI: 1.0356-1.211, p = 0.005). TMT did not show a significant association with other factors (p > 0.05). Notably, age demonstrated a significant difference between the thicker and thinner groups (p = 0.019). Our study revealed that WHO grade and BMI demonstrated significant prognostic value for survival outcomes. Consequently, TMT does not appear to be a significant or applicable predictor in patients with high WHO grades.

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颞肌厚度并非高级别胶质瘤患者的预后预测指标--中国两个中心的经验。

颞肌厚度（TMT）是肌肉疏松症的一个指标，对多种癌症具有预测价值。本研究旨在评估颞肌厚度对高级别胶质瘤患者的预后意义。研究对 2015 年 1 月至 2022 年 12 月期间的 172 例高级别胶质瘤患者进行了回顾性研究。TMT值根据手术前对比增强T1加权磁共振图像进行测量。采用皮尔逊分析评估潜在的相关性。Cox回归分析用于评估高级别胶质瘤患者的总生存率。在我们的研究中，TMT的临界值被确定为7.4毫米。TMT值对高级别胶质瘤患者的预后预测作用不明显（危险比 [HR]：1.151，95% 置信区间 [CI]：0.9299-1.424, p = 0.196).世界卫生组织（WHO）VI和高体重指数（BMI）值与较差的生存结果显著相关（HR：2.6689，95% CI：1.5729-4.528，p <0.001；HR：1.120，95% CI：1.0356-1.211，p = 0.005）。TMT与其他因素无明显关联（P > 0.05）。值得注意的是，年龄在较厚组和较薄组之间存在明显差异（p = 0.019）。我们的研究表明，WHO 分级和体重指数对生存结果具有重要的预后价值。因此，对于 WHO 分级较高的患者，TMT 似乎不是一个重要或适用的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.