A 3D genome view of colon cancer initiation

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-10-30 DOI:10.1038/s43018-024-00825-x

Adi Danieli-Mackay, Argyris Papantonis

引用次数: 0

Abstract

The early molecular events driving cancer initiation remain elusive, hampering prognostic accuracy. A comparative analysis of 3D genomics data from all stages of colon malignant transformation now reveals that altered connectivity of gene promoters with cognate enhancers is both predictive of and rate-limiting in neoplasia.

Abstract Image

查看原文本刊更多论文

结肠癌发病的三维基因组视图。

驱动癌症发生的早期分子事件仍然难以捉摸，影响了预后的准确性。对结肠恶性转化各个阶段的三维基因组学数据进行比较分析后发现，基因启动子与同源增强子的连接改变既能预测肿瘤的发生，又能限制肿瘤的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.