Combined use of 5-ALA-induced protoporphyrin IX and chlorin e6 for fluorescence diagnostics and photodynamic therapy of skin tumors.

IF 2.1 4区医学 Q3 ENGINEERING, BIOMEDICAL

Lasers in Medical Science Pub Date : 2024-10-31 DOI:10.1007/s10103-024-04219-4

Kanamat Efendiev, Polina Alekseeva, Alexey Skobeltsin, Artem Shiryaev, Tatiana Pisareva, Fatima Akhilgova, Alena Mamedova, Igor Reshetov, Victor Loschenov

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Abstract

Different types of photosensitizers (PSs) have different dynamics and intensities of accumulation, depending on the type of tumor or different areas within the same tumor. This determines the effectiveness of fluorescence diagnostics and photodynamic therapy (PDT). This paper studies the processes of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) and chlorin e6 (Ce6) accumulation in the central and border zones of a tumor after combined administration of two PSs into the patient's body. Fluorescence diagnostic methods have shown that sublingual administration of 5-ALA leads to the more intense accumulation of PpIX in a tumor compared to oral administration. Differences have been identified in the dynamics of 5-ALA-induced PpIX and Ce6 accumulation in the central and border zones of the tumor, as well as normal tissues. Ce6 accumulates mainly in the central zone of the tumor while PpIX accumulates in the border zone of the tumor. All patients with combined PDT experienced complete therapeutic pathomorphosis and relapse-free observation.

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将 5-ALA 诱导的原卟啉 IX 和氯素 e6 联合用于皮肤肿瘤的荧光诊断和光动力疗法。

根据肿瘤类型或同一肿瘤的不同区域，不同类型的光敏剂（PSs）具有不同的积累动态和强度。这决定了荧光诊断和光动力疗法（PDT）的效果。本文研究了患者体内联合使用两种 PS 后，5-氨基乙酰丙酸（5-ALA）诱导的原卟啉 IX（PpIX）和氯蛋白 e6（Ce6）在肿瘤中心区和边界区的积累过程。荧光诊断方法表明，与口服给药相比，舌下含服 5-ALA 会导致 PpIX 在肿瘤中更密集地积累。研究发现，5-ALA 诱导的 PpIX 和 Ce6 在肿瘤中心区和边界区以及正常组织中的积累动态存在差异。Ce6 主要积聚在肿瘤中心区，而 PpIX 则积聚在肿瘤边界区。所有接受联合光动力疗法的患者都获得了完全的治疗性病理形态改变，并且无复发观察。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Medical Science 医学-工程：生物医学

CiteScore

4.50

自引率

4.80%

发文量

192

审稿时长

3-8 weeks

期刊介绍： Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.