Description of FDG and Prostate-Specific Membrane Antigen PET/CT Findings in Korean Patients With Advanced Metastatic Castration-Resistant Prostate Cancer.

IF 4.4 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Sae Jung Na, Seunggyun Ha, In-Ho Kim, Ji Youl Lee, Joo Hyun O
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引用次数: 0

Abstract

Objective: We aimed to describe the [18F]fluorodeoxyglucose (FDG) and prostate-specific membrane antigen (PSMA) PET/CT findings in Korean men with advanced metastatic castration-resistant prostate cancer (mCRPC).

Materials and methods: The results of paired FDG and PSMA PET/CT examinations performed in 42 consecutive men with prostate cancer for treatment planning after failure of anti-androgen therapy and chemotherapy were studied. Tumor lesions with FDG or PSMA uptake intensity higher than that of the liver on visual review were considered positive and noted per patient and tumor site (prostate bed, lymph node, bone, and visceral organ). The presence of unequivocally discordant FDG and PSMA uptake patterns in tumor lesions was assessed. Patients were grouped according to the total tumor volume as seen on each PET/CT scan, and the clinical findings between the patient groups were compared using the Mann-Whitney U test.

Results: On patient-based analysis, the image findings were PSMA+/FDG- in 2 patients, PSMA-/FDG+ in one, and PSMA+/FDG+ in 39 patients. On site-based analysis, the discordance (PSMA+/FDG- or PSMA-/FDG+) rate was 9.5% (4/42) for prostate/bed, 11.9% (5/42) for lymph nodes, 9.5% (4/42) for bones, and 11.9% (5/42) for visceral organs. FDG uptake was higher than PSMA uptake in at least one tumor site in 54.8% (23/42) of patients. Patients with greater total tumor volume on FDG PET/CT than that on PSMA PET/CT ("FDG-dominant pattern") accounted for 28.6% (12/42), and they had significantly shorter time from diagnosis (median 25 months vs. 62 months, P = 0.049), and higher aspartate aminotransferase (median 28.5 vs. 22.5, P = 0.027) and lactate dehydrogenase (median 341.5 vs. 224.5, P = 0.010) levels.

Conclusion: Most patients with advanced mCRPC had tumors with positive findings on both FDG and PSMA PET/CT. However, the uptake patterns varied; 54.8% of the patients had tumor(s) with FDG uptake greater than PSMA uptake, and FDG-dominant pattern was noted in 28.6% of the patients.

描述韩国晚期转移性钙化抗性前列腺癌患者的 FDG 和前列腺特异性膜抗原 PET/CT 发现。
研究目的我们旨在描述韩国晚期转移性去势抵抗性前列腺癌(mCRPC)男性患者的[18F]氟脱氧葡萄糖(FDG)和前列腺特异性膜抗原(PSMA)PET/CT检查结果:材料和方法: 研究了在抗雄激素治疗和化疗失败后为制定治疗计划而对42名连续男性前列腺癌患者进行的FDG和PSMA PET/CT配对检查结果。肉眼观察FDG或PSMA摄取强度高于肝脏的肿瘤病灶被视为阳性,并按患者和肿瘤部位(前列腺床、淋巴结、骨和内脏器官)进行记录。评估肿瘤病灶中是否存在明显不一致的 FDG 和 PSMA 摄取模式。根据每次 PET/CT 扫描所见的肿瘤总体积对患者进行分组,并使用 Mann-Whitney U 检验比较各组患者的临床结果:基于患者的分析结果显示,2 名患者的图像结果为 PSMA+/FDG-,1 名患者的图像结果为 PSMA-/FDG+,39 名患者的图像结果为 PSMA+/FDG+。根据部位分析,前列腺/床的不一致率(PSMA+/FDG- 或 PSMA-/FDG+)为 9.5%(4/42),淋巴结为 11.9%(5/42),骨骼为 9.5%(4/42),内脏器官为 11.9%(5/42)。54.8%(23/42)的患者至少有一个肿瘤部位的 FDG 摄取高于 PSMA 摄取。FDG PET/CT显示的肿瘤总体积大于PSMA PET/CT显示的肿瘤总体积("FDG主导模式")的患者占28.6%(12/42),他们的确诊时间明显更短(中位25个月对62个月,P = 0.049),天冬氨酸氨基转移酶(中位28.5对22.5,P = 0.027)和乳酸脱氢酶(中位341.5对224.5,P = 0.010)水平更高:结论:大多数晚期mCRPC患者的肿瘤在FDG和PSMA PET/CT检查中均呈阳性。结论:大多数晚期mCRPC患者的肿瘤在FDG和PSMA PET/CT检查中均呈阳性,但摄取模式各不相同;54.8%的患者肿瘤的FDG摄取高于PSMA摄取,28.6%的患者以FDG为主。
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来源期刊
Korean Journal of Radiology
Korean Journal of Radiology 医学-核医学
CiteScore
10.60
自引率
12.50%
发文量
141
审稿时长
1.3 months
期刊介绍: The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences. A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge. World''s outstanding radiologists from many countries are serving as editorial board of our journal.
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