The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of International Medical Research Pub Date : 2024-10-01 DOI:10.1177/03000605241287163

Cheng Geng, Junxiang Zhang, Shixing Wu, Bolin Zhang, Xinxin Tian, Tigu A, Hongde Su, Xinjian Xu

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引用次数: 0

Abstract

Objective: To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP).

Methods: A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-κB and NF-κB p65. Serum levels of amylase (α-AMY), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 were also compared between groups of rats.

Results: The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-κB and NF-κB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. α-AMY, TNF-α and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24 h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group.

Conclusions: Serum IMA level was associated with inflammatory markers and NF-κB p65 in rats with AP.

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缺血修饰白蛋白在急性胰腺炎预后中的作用及其与 NF-κB 介导的炎症反应的相关性。

目的研究急性胰腺炎（AP）大鼠血清中缺血修饰白蛋白（IMA）水平与疾病严重程度之间的相关性：方法：建立大鼠急性胰腺炎模型，分析各组在不同时间点的血液样本。实验结束后，收集大鼠的胰腺组织进行病理检查，并测量 NF-κB 和 NF-κB p65 的蛋白水平。此外，还比较了各组大鼠血清中淀粉酶（α-AMY）、肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6 和 IL-8 的水平：结果：重症急性胰腺炎（SAP）组的血清 IMA 浓度高于轻症急性胰腺炎（MAP）组。MAP组和SAP组的NF-κB和NF-κB p65蛋白水平呈时间依赖性升高。α-AMY、TNF-α 和 IL-6 在 MAP 组和 SAP 组的所有时间点均有所增加。SAP组在24小时内增幅最大。从胰腺、肾脏和肺组织的病理变化来看，SAP 组的损伤比 MAP 组更为明显：结论：AP大鼠血清IMA水平与炎症标志物和NF-κB p65相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605