The value of lncRNAs as a biomarker for the pregnancy outcomes of gestational diabetes: a meta-analysis.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2024-10-29 DOI:10.1007/s11845-024-03828-w

Chunling Bao, Jun Kuang, Chuanyong He, Hui Xu

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引用次数: 0

Abstract

Background: Long non-coding RNAs (lncRNAs) are tissue-specific and highly stable and may serve as early molecular markers of adverse pregnancy outcomes in patients with gestational diabetes mellitus (GDM).

Aims: This study aimed to investigate the relationship between aberrant expression of lncRNAs and adverse pregnancy outcomes in GDM patients.

Methods: We searched electronic databases: Embase, Medline, EBSCO, PubMed, CNKI, and Wanfang databases to find relevant articles. Included studies quality was assessed using the QUADAS-2 quality assessment tool. Prognostic value of lncRNAs were pooled using risk ratio (RR) with 95% confidence interval (95%CI). The heterogeneity was analyzed using the Cochran Q test and I² statistical test, and subgroup analyses were performed to explore the sources of heterogeneity. Begg's test funnel plots were analyzed for publication bias.

Results: The review included nine studies. Overall, the review found that altered expression of lncRNAs was associated with adverse pregnancy outcomes of GDM patients (RR: 1.616, 95%CI: 1.308-1.996), and was a risk factor for adverse pregnancy outcomes both of Infants (RR: 1.68, 95% CI: 1.30-2.17) and maternal (RR: 4.14, 95% CI: 1.90-9.03) in patients with GDM. The diagnostic procedure, diagnostic criteria, expression trend of lncRNAs, and adverse pregnancy outcomes were the sources of heterogeneity.

Conclusions: Aberrant expression of lncRNAs was strongly associated with the adverse pregnancy outcomes in GDM.

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lncRNA作为妊娠糖尿病妊娠结局生物标志物的价值：一项荟萃分析。

背景：长非编码RNA（lncRNA）具有组织特异性和高度稳定性，可作为妊娠糖尿病（GDM）患者不良妊娠结局的早期分子标记：方法：我们检索了电子数据库：方法：我们检索了电子数据库：Embase、Medline、EBSCO、PubMed、CNKI 和万方数据库，以查找相关文章。采用QUADAS-2质量评估工具对纳入的研究进行质量评估。采用风险比（RR）和95%置信区间（95%CI）对lncRNA的预后价值进行汇总。使用 Cochran Q 检验和 I2 统计检验分析异质性，并进行亚组分析以探索异质性的来源。对贝格氏检验漏斗图进行了发表偏倚分析：综述包括九项研究。总体而言，综述发现，lncRNAs表达的改变与GDM患者的不良妊娠结局相关（RR：1.616，95%CI：1.308-1.996），并且是GDM患者婴儿（RR：1.68，95%CI：1.30-2.17）和母亲（RR：4.14，95%CI：1.90-9.03）不良妊娠结局的风险因素。诊断程序、诊断标准、lncRNAs的表达趋势和不良妊娠结局是异质性的来源：lncRNAs的异常表达与GDM的不良妊娠结局密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.