Correlation between gut microbiota and pancreatitis: a bidirectional Mendelian randomization.

IF 2.3 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI:10.1097/MEG.0000000000002861

Boyuan Nan, Luyuan Jin, Tianze Wang, Chao Long, Hao Zhao, Chunhui Wang, Wei Zhang

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引用次数: 0

Abstract

Objective: The causative role of gut microbiota in pancreatitis remains unknown. This study aimed to investigate potential causal associations between gut microbiota and pancreatitis, using bidirectional Mendelian randomization (MR) analysis.

Methods: We analyzed genome-wide association study (GWAS) summary statistics for gut microbiota (211 taxa from gut microbiota, n = 18 340) and two types of pancreatitis, namely acute pancreatitis (AP, 5509 cases and 301 383 controls) and chronic pancreatitis (CP, 3002 cases and 301 383 controls). A reverse MR analysis was also performed to assess the possibility of reverse causation.

Results: Nine features (one family + eight genera) showed a causal association with AP. According to inverse-variance weighted (IVW) estimates, phylum Firmicutes ( P = 4.10 × 10 -2 ), genus Erysipelatoclostridium ( P = 4.80 × 10 -2 ), genus Flavonifractor ( P = 4.10 × 10 -2 ), genus Methanobrevibacter ( P = 3.40 × 10 -2 ), and genus Prevotella9 ( P = 4.60 × 10 -2 ) were found to have a protective effect on AP. Additionally, genus Eubacteriumeligensgroup ( P = 4.10 × 10 -2 ), genus Eubacteriumfissicatenagroup ( P = 4.00 × 10 -3 ), genus Coprococcus3 ( P = 4.10 × 10 -2 ), and genus Haemophilus ( P = 4.60 × 10 -2 ) exhibited a positive correlation with AP. Four features (two families + two genera) were causally associated with CP. IVW results also confirmed that family Clostridiaceae1 ( P = 3.30 × 10 -2 ), genus LachnospiraceaeFCS020group ( P = 4.60 × 10 -2 ), and genus Prevotella9 ( P = 1.90 × 10 -2 ) were protective factors for CP, whereas the presence of family Victivallaceae ( P = 2.60 × 10 -2 ) correlated with CP risk. No causal effects of pancreatitis (AP or CP) on these gut microbiota taxa were found in the reverse MR analysis.

Conclusion: This study confirms a potential causal relationship between gut microbiota and pancreatitis, highlighting the gut microbiota-pancreas axis in the pathogenesis of pancreatitis.

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肠道微生物群与胰腺炎之间的相关性：双向孟德尔随机试验。

目的：肠道微生物群在胰腺炎中的致病作用仍然未知。本研究旨在通过双向孟德尔随机化（MR）分析，研究肠道微生物群与胰腺炎之间的潜在因果关系：我们分析了肠道微生物群（来自肠道微生物群的 211 个分类群，n = 18 340）与两种类型胰腺炎（即急性胰腺炎（AP，5509 例，301 383 例对照）和慢性胰腺炎（CP，3002 例，301 383 例对照））的全基因组关联研究（GWAS）汇总统计。还进行了反向 MR 分析，以评估反向因果关系的可能性：结果：九个特征（1 个科 + 8 个属）与 AP 存在因果关系。根据逆方差加权（IVW）估算，发现真菌门（P = 4.10 × 10-2）、红细胞菌属（P = 4.80 × 10-2）、黄杆菌属（P = 4.10 × 10-2）、甲烷杆菌属（P = 3.40 × 10-2）和普雷沃特氏菌属9（P = 4.60 × 10-2）对 AP 有保护作用。此外，Eubacteriumeligensgroup 属（P = 4.10 × 10-2）、Eubacteriumfissicatenagroup 属（P = 4.00 × 10-3）、Coprococcus3 属（P = 4.10 × 10-2）和嗜血杆菌属（P = 4.60 × 10-2）与 AP 呈正相关。有四个特征（两个科 + 两个属）与 CP 存在因果关系。IVW 结果还证实，梭菌科1（P = 3.30 × 10-2）、LachnospiraceaeFCS020group 属（P = 4.60 × 10-2）和 Prevotella9 属（P = 1.90 × 10-2）是 CP 的保护因素，而 Victivallaceae 科（P = 2.60 × 10-2）的存在与 CP 风险相关。在反向 MR 分析中，没有发现胰腺炎（AP 或 CP）对这些肠道微生物群分类群的因果效应：本研究证实了肠道微生物群与胰腺炎之间的潜在因果关系，强调了肠道微生物群-胰腺轴在胰腺炎发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.