Prevalence and associated factors of physical injuries among patients with epilepsy in Sub-Sharan Africa: A systematic review and meta-analysis

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-30 DOI:10.1016/j.yebeh.2024.110099

Gebremeskel Kibret Abebe , Biruk Beltew Abate , Alemu Birara Zemariam , Molla Azmeraw , Habtamu Setegne Ngusie , Melesse Abiye Munie , Amsalu Baylie Taye , Bogale Molla , Befkad Derese Tilahun , Addis Wondmagegn Almaw

{"title":"Prevalence and associated factors of physical injuries among patients with epilepsy in Sub-Sharan Africa: A systematic review and meta-analysis","authors":"Gebremeskel Kibret Abebe , Biruk Beltew Abate , Alemu Birara Zemariam , Molla Azmeraw , Habtamu Setegne Ngusie , Melesse Abiye Munie , Amsalu Baylie Taye , Bogale Molla , Befkad Derese Tilahun , Addis Wondmagegn Almaw","doi":"10.1016/j.yebeh.2024.110099","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Globally, 50 million people suffer from epilepsy, with more than 80% of patients with epilepsy living in low‐ and middle‐income countries. The World Health Organization (WHO) estimates that approximately 25 million people in Africa have epilepsy. In Sub-Saharan Africa, 50 % of patients with epilepsy experience seizure-related physical injuries, including burns, fractures, motor vehicle accidents, dental injury, soft-tissue injuries, and submersion accidents.</div></div><div><h3>Objective</h3><div>This systematic review and meta-analysis was conducted to assess the prevalence and associated factors of physical injuries among patients with epilepsy in Sub-Sharan Africa.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted between January 2012 and December 2023. An experienced librarian performed a thorough search across several databases, including PubMed, Medline, the Cochrane Database of Systematic Reviews, Up To Date, EMBASE, and NICE (National Institute for Health and Care Excellence). The search also included grey literature and unpublished studies. Data were extracted on the prevalence of physical injuries and associated factors among patients with epilepsy in Sub-Saharan Africa. A pooled analysis of prevalence was conducted using a random-effects model, and a systematic review of risk factors for physical injuries was performed.</div></div><div><h3>Results</h3><div>A total of seven studies (n = 1724) were included. The pooled prevalence physical of injuries among patients with epilepsy in Sub-Sharan Africa is found to be 63.68 % (95 % CI: 62.15, 65.22; I2 = 99.7 %; p < 0.0001). Subgroup analyses were conducted by grouping the studies by country. We also employed a leave-one-out sensitivity analysis to identify potential sources of heterogeneity. Publication bias was assessed by visual inspection of meta-funnel plot and egger, begs test, and revealed there was no publication bias.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis can be used for policy maker, stakeholders and concerned body to set strategies to prevent seizure-related physical injuries among patients with epilepsy. The finding also allows clinicians to provide appropriate patient care.</div></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525505024004815","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Globally, 50 million people suffer from epilepsy, with more than 80% of patients with epilepsy living in low‐ and middle‐income countries. The World Health Organization (WHO) estimates that approximately 25 million people in Africa have epilepsy. In Sub-Saharan Africa, 50 % of patients with epilepsy experience seizure-related physical injuries, including burns, fractures, motor vehicle accidents, dental injury, soft-tissue injuries, and submersion accidents.

Objective

This systematic review and meta-analysis was conducted to assess the prevalence and associated factors of physical injuries among patients with epilepsy in Sub-Sharan Africa.

Methods

A systematic review and meta-analysis were conducted between January 2012 and December 2023. An experienced librarian performed a thorough search across several databases, including PubMed, Medline, the Cochrane Database of Systematic Reviews, Up To Date, EMBASE, and NICE (National Institute for Health and Care Excellence). The search also included grey literature and unpublished studies. Data were extracted on the prevalence of physical injuries and associated factors among patients with epilepsy in Sub-Saharan Africa. A pooled analysis of prevalence was conducted using a random-effects model, and a systematic review of risk factors for physical injuries was performed.

Results

A total of seven studies (n = 1724) were included. The pooled prevalence physical of injuries among patients with epilepsy in Sub-Sharan Africa is found to be 63.68 % (95 % CI: 62.15, 65.22; I2 = 99.7 %; p < 0.0001). Subgroup analyses were conducted by grouping the studies by country. We also employed a leave-one-out sensitivity analysis to identify potential sources of heterogeneity. Publication bias was assessed by visual inspection of meta-funnel plot and egger, begs test, and revealed there was no publication bias.

Conclusion

This systematic review and meta-analysis can be used for policy maker, stakeholders and concerned body to set strategies to prevent seizure-related physical injuries among patients with epilepsy. The finding also allows clinicians to provide appropriate patient care.

查看原文本刊更多论文

非洲撒哈拉以南地区癫痫患者身体伤害的发生率和相关因素：系统回顾和荟萃分析。

背景：全球有 5000 万癫痫患者，其中 80% 以上生活在中低收入国家。据世界卫生组织（WHO）估计，非洲约有 2500 万癫痫患者。在撒哈拉以南非洲地区，50%的癫痫患者经历过与癫痫发作有关的身体伤害，包括烧伤、骨折、机动车事故、牙齿损伤、软组织损伤和浸水事故：本系统综述和荟萃分析旨在评估撒哈拉以南非洲地区癫痫患者身体伤害的发生率和相关因素：2012年1月至2023年12月期间进行了系统综述和荟萃分析。一位经验丰富的图书管理员对多个数据库进行了全面检索，包括 PubMed、Medline、Cochrane 系统性综述数据库、Up To Date、EMBASE 和 NICE（美国国家健康与护理优化研究所）。搜索还包括灰色文献和未发表的研究。研究人员提取了撒哈拉以南非洲地区癫痫患者身体伤害发生率及相关因素的数据。采用随机效应模型对患病率进行了汇总分析，并对身体伤害的风险因素进行了系统回顾：共纳入了七项研究（n = 1724）。结果：共纳入了 7 项研究（n = 1724 例），发现撒哈拉以南非洲地区癫痫患者身体受伤的总体流行率为 63.68 %（95 % CI：62.15, 65.22；I2 = 99.7 %；p 结论：该系统综述和荟萃分析结果表明，在撒哈拉以南非洲地区的癫痫患者中，身体受伤的流行率为 63.68 %：这项系统回顾和荟萃分析可供决策者、利益相关者和相关机构用于制定战略，以预防癫痫患者中与癫痫发作相关的身体伤害。临床医生也可根据研究结果为患者提供适当的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464