Mathematics skills in children with genetic generalized epilepsy: Cognitive and clinical correlates. Preliminary results

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2024-10-30 DOI:10.1016/j.yebeh.2024.110110

Belinda J. Poole , Natalie L. Phillips , Camilla Gilmore , Anna Mandalis , John Lawson , Richard Webster , Kavitha Kothur , Samantha McLean , Suncica Lah

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引用次数: 0

Abstract

Impairments in mathematics have been found in children with Genetic Generalized Epilepsy (GGE), yet little is known about the underpinnings of these difficulties. The aim of this study was to investigate basic numeracy and secondary mathematics skills in GGE and explore cognitive and clinical correlates that relate to those skills. Nineteen children with GGE and 22 typically developing controls aged 8–16 years completed a neuropsychological battery which assessed: (i) basic numeracy skills: non-symbolic and symbolic magnitude comparison; (ii) secondary mathematics skills: calculation, reasoning, and fluency; and (iii) cognitive skills: intelligence, fluid reasoning, processing speed, and working memory. Epilepsy clinical factors (age of epilepsy onset, duration of epilepsy, number of anti-seizure medications) were also recorded. Children with GGE were impaired in select basic numeracy skills (non-symbolic magnitude comparison), and all secondary mathematics skills compared to controls. In children with GGE, the visuo-spatial central executive correlated with both basic numeracy skills. The verbal central executive correlated with mathematics reasoning. Non-verbal intelligence was related to symbolic magnitude comparison and mathematics reasoning. Fluid reasoning was correlated with non-symbolic magnitude comparison and mathematics problems solving. Epilepsy variables did not relate to mathematics outcomes. Overall, we found that children with GGE experience significant difficulties in select basic numeracy and all secondary mathematics skills. Risk factors for mathematics difficulties included reduced working memory capacity, lower intelligence and fluid reasoning. Our findings suggest that children with GGE may require accommodation for limited central executive working memory capacity in combination with academic supports for poor mathematics skills.

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遗传性全身性癫痫患儿的数学能力：认知和临床相关性。初步结果。

在遗传性广泛性癫痫（GGE）患儿中发现了数学障碍，但人们对这些困难的根源知之甚少。本研究旨在调查遗传性广泛性癫痫儿童的基本计算能力和中学数学技能，并探索与这些技能相关的认知和临床相关因素。19 名 GGE 儿童和 22 名发育正常的 8-16 岁对照组儿童完成了神经心理测试，测试内容包括：(i) 基本计算技能：非符号和符号大小比较；(ii) 中等数学技能：计算、推理和流畅性；(iii) 认知技能：智力、流畅推理、处理速度和工作记忆。此外，还记录了癫痫临床因素（癫痫发病年龄、癫痫持续时间、服用抗癫痫药物的次数）。与对照组相比，患有遗传性癫痫的儿童在某些基本计算技能（非符号大小比较）和所有中等数学技能方面都存在缺陷。在有遗传性脑震荡的儿童中，视觉空间中枢执行器与这两项基本计算技能相关。语言中枢执行器与数学推理相关。非语言智能与符号大小比较和数学推理有关。流体推理与非符号大小比较和数学问题解决相关。癫痫变量与数学结果无关。总体而言，我们发现患有遗传性癫痫的儿童在选择基本运算能力和所有中学数学技能时会遇到很大困难。数学困难的风险因素包括工作记忆能力下降、智力和流体推理能力较低。我们的研究结果表明，一般性别问题儿童可能需要对有限的中枢执行工作记忆能力进行调适，同时对数学技能较差的儿童提供学业支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.