Una Glamočlija, Lejla Mahmutovic, Esma Bilajac, Violeta Šoljić, Katarina Vukojević, Abas Sezer, Mirza Suljagić
{"title":"Single and Combinatorial Effects of Metformin and Thymoquinone in Diffuse Large B Cell Lymphoma Cells.","authors":"Una Glamočlija, Lejla Mahmutovic, Esma Bilajac, Violeta Šoljić, Katarina Vukojević, Abas Sezer, Mirza Suljagić","doi":"10.1002/cbdv.202401533","DOIUrl":null,"url":null,"abstract":"<p><p>Diffuse large B cell lymphoma (DLBCL) is classified into Germinal Center B-cell (GCB) and activated B-cell (ABC) subgroups originating from different stages of lymphoid differentiation. Cell of origin dictates the behavior and therapeutic response of DLBCL. This study aimed to evaluate single and combinatorial effects of metformin and thymoquinone (TQ) in two DLBCL cell lines belonging to GCB and ABC subtypes. Metformin and TQ caused dose-dependent responses in both ABC and GCB DLBCL subtypes. Metformin had a greater impact on the ABC subtype while TQ demonstrated more pronounced effects on the GCB subtype. Synergistic effects were observed in the DHL4 (GCB subtype) but not in the HBL1 (ABC subtype) cell line. This is the first study to compare the effects of metformin and TQ in ABC versus GCB subtype of DLBCL. It brings valuable results that could be utilized in further research aimed at reshaping treatments for subtype-specific lymphomas.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/cbdv.202401533","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Diffuse large B cell lymphoma (DLBCL) is classified into Germinal Center B-cell (GCB) and activated B-cell (ABC) subgroups originating from different stages of lymphoid differentiation. Cell of origin dictates the behavior and therapeutic response of DLBCL. This study aimed to evaluate single and combinatorial effects of metformin and thymoquinone (TQ) in two DLBCL cell lines belonging to GCB and ABC subtypes. Metformin and TQ caused dose-dependent responses in both ABC and GCB DLBCL subtypes. Metformin had a greater impact on the ABC subtype while TQ demonstrated more pronounced effects on the GCB subtype. Synergistic effects were observed in the DHL4 (GCB subtype) but not in the HBL1 (ABC subtype) cell line. This is the first study to compare the effects of metformin and TQ in ABC versus GCB subtype of DLBCL. It brings valuable results that could be utilized in further research aimed at reshaping treatments for subtype-specific lymphomas.
弥漫大 B 细胞淋巴瘤（DLBCL）分为生殖中心 B 细胞（GCB）亚组和活化 B 细胞（ABC）亚组，它们起源于淋巴分化的不同阶段。起源细胞决定了 DLBCL 的行为和治疗反应。本研究旨在评估二甲双胍和胸腺醌（TQ）在两种属于GCB和ABC亚型的DLBCL细胞系中的单一作用和组合作用。二甲双胍和胸腺醌对ABC和GCB两种DLBCL亚型均产生了剂量依赖性反应。二甲双胍对ABC亚型的影响更大，而TQ对GCB亚型的影响更明显。在DHL4（GCB亚型）细胞系中观察到了协同效应，但在HBL1（ABC亚型）细胞系中没有观察到。这是第一项比较二甲双胍和TQ对ABC亚型和GCB亚型DLBCL作用的研究。它带来了有价值的结果，可用于旨在重塑亚型特异性淋巴瘤治疗方法的进一步研究。
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
