Determination of methotrexate using carbon paste electrode modified with ionic liquid/Ni-Co layered double hydroxide nanosheets as a voltammetric sensor.

IF 3.4 Q2 CHEMISTRY, MEDICINAL

ADMET and DMPK Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI:10.5599/admet.2460

Peyman Mohammadzadeh Jahani, Fariba Garkani Nejad, Reza Zaimbashi, Mohammad Reza Aflatoonian, Somayeh Tajik, Hadi Beitollahi

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引用次数: 0

Abstract

Background and purpose: Methotrexate (MTX) is a widely used anti-cancer drug, but its overuse can lead to significant side effects. Therefore, it is very vital to design simple and sensitive analytical methods for its determination.

Experimental approach: In this work, an electrochemical sensor was prepared based on an ionic liquid (IL)/Ni-Co layered double hydroxide nanosheets (Ni-Co-LDH)-modified carbon paste electrode IL/Ni-Co-LDH/CPE. Cyclic voltammetry, differential pulse voltammetry, and chronoamperometry methods were applied to evaluate the performance of the designed sensor for MTX determination.

Key results: The IL/Ni-Co-LDH/CPE sensor exhibits a linear relationship between the peak current of the differential pulse voltammetry and MTX concentrations in the linear dynamic range of 0.02 to 140.0 μM, with a detection limit of 0.006 μM. The IL/Ni-Co-LDH/CPE sensor exhibited relative standard deviation values between 1.7 to 3.7 % for recovery tests on real samples, indicating the precision of the method.

Conclusion: The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.

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使用离子液体/镍钴层状双氢氧化物纳米片修饰的碳浆电极作为伏安传感器测定甲氨蝶呤。

背景和目的：甲氨蝶呤（MTX）是一种广泛使用的抗癌药物，但过度使用会导致严重的副作用。因此，设计简单灵敏的分析方法来测定该药物至关重要：在这项工作中，制备了一种基于离子液体（IL）/镍-钴层状双氢氧化物纳米片（Ni-Co-LDH）改性碳浆电极 IL/Ni-Co-LDH/CPE 的电化学传感器。应用循环伏安法、差分脉冲伏安法和时变法评估了所设计的传感器在测定 MTX 方面的性能：主要结果：IL/Ni-Co-LDH/CPE 传感器的差分脉冲伏安法峰值电流与 MTX 浓度之间呈线性关系，线性动态范围为 0.02 至 140.0 μM，检测限为 0.006 μM。IL/Ni-Co-LDH/CPE 传感器在实际样品的回收率测试中显示的相对标准偏差值在 1.7 % 到 3.7 % 之间，表明该方法的精确性：结论：所设计的传感器成本低、性能好，可用于治疗药物监测和临床诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ADMET and DMPK Multiple-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study