Bioconjugated Antibody-Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two-Step Immunomodulation of Myeloid Cells (Adv. Healthcare Mater. 27/2024)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2024-10-28 DOI:10.1002/adhm.202470171

Soyoung Park, Seung Mo Jin, Suhyeon Kim, Ju Hee Cho, JungHyub Hong, Yong-Soo Bae, Yong Taik Lim

引用次数: 0

Abstract

Antibody-Trojan Immune Converter

In article 2401270 by Yong Taik Lim and co-worker, a programmed two-step activation strategy is suggested to enhance cancer immunotherapy with minimized systemic toxicities via Antibody-Trojan Immune Converter Conjugates that specifically targets myeloid cells by anti-SIRPα followed by reactivation of transiently inactivated Trojan TLR7/8 agonist after antibody-mediated endocytosis.

Abstract Image

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生物共轭抗体-特洛伊免疫转换器通过对髓系细胞进行程序化两步免疫调节，以最小的毒性增强癌症免疫疗法（Adv. Healthcare Mater.）

抗体-特洛伊免疫转换器在 Yong Taik Lim 及其合作者发表的 2401270 号文章中，提出了一种程序化的两步激活策略，通过抗体-特洛伊免疫转换器共轭物增强癌症免疫疗法，并将全身毒性降到最低，该共轭物通过抗 SIRPα 特异性靶向髓系细胞，然后在抗体介导的内吞作用后重新激活瞬时失活的特洛伊 TLR7/8 激动剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.