Adenosine triphosphate-responsive carbon dots nanoreactors for T1-weighted magnetic resonance imaging-guided tumor chemodynamic therapy

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2024-09-25 DOI:10.1007/s40843-024-3038-8

Fuchun Nan (, ), Xiaokuang Xue (, ), Jian Li (, ), Ke Liang (, ), Jian Wang (, ), William W. Yu (, ), Jiechao Ge (, ), Pengfei Wang (, )

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引用次数: 0

Abstract

There are various strategies to conduct tumor microenvironment (TME) stimulus-responsive (e.g., acid, H₂O₂ or glutathione) nanoreactors for increasing the efficiency of chemodynamic therapy (CDT). Among these, the exploitation of adenosine triphosphate (ATP, another over-expressed biomarker in TME)-responsive nanoreactors for tumor CDT is still challenging. Herein, the ATP-responsive iron-doped CDs (FeCDs) were firstly prepared and then co-assembled with glucose oxidase (GOx) to obtain FeCDs/GOx liposomes as ATP-responsive nanoreactors. Under TME conditions, the nanoreactors initially released FeCDs and GOx. Subsequently, with the existence of ATP, iron ions were rapidly released from the FeCDs to trigger Fenton/Fenton-like reactions for generating ·OH. Meanwhile, the T₁-weighted magnetic resonance imaging (MRI) was achieved due to the released iron ions. Moreover, the GOx converted endogenous glucose in tumor to gluconic acid and H₂O₂ to satisfy the requirement of ·OH generation. In vitro as well as in vivo experiments illustrated that the obtained ATP-responsive CD nanoreactors could be used as a versatile nanotheranostics for simultaneously T₁-weighted MRI-guided tumor CDT. This work presents a new ATP-responsive nanoreactor with self-supplied H₂O₂ for multifunctional nanotheranostic applications.

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用于 T1 加权磁共振成像引导的肿瘤化学动力疗法的三磷酸腺苷响应型碳点纳米反应器

为提高化学动力疗法（CDT）的效率，有多种策略来开发肿瘤微环境（TME）刺激响应型（如酸、H2O2 或谷胱甘肽）纳米反应器。其中，利用三磷酸腺苷（ATP，TME中另一种过度表达的生物标志物）响应型纳米反应器进行肿瘤化学动力学治疗仍具有挑战性。本文首先制备了ATP响应的掺铁CDs（FeCDs），然后与葡萄糖氧化酶（GOx）共同组装得到FeCDs/GOx脂质体作为ATP响应的纳米反应器。在 TME 条件下，纳米反应器最初释放出 FeCDs 和 GOx。随后，随着 ATP 的存在，铁离子迅速从 FeCDs 中释放出来，引发 Fenton/Fenton 类反应，生成 -OH。同时，由于铁离子的释放，T1 加权磁共振成像（MRI）得以实现。此外，GOx 还能将肿瘤中的内源性葡萄糖转化为葡萄糖酸和 H2O2，从而满足产生 -OH 的要求。体外和体内实验表明，所获得的 ATP 响应型 CD 纳米反应器可作为一种多功能纳米otheranostics，同时用于 T1 加权磁共振成像引导的肿瘤 CDT。这项工作提出了一种新的 ATP 响应型纳米反应器，它具有自我供应 H2O2 的功能，可用于多功能纳米otheranostic 应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.