Harnessing bacterial metabolites for enhanced cancer chemotherapy: unveiling unique therapeutic potentials

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Aroni Chatterjee, Rajni Khan, Triparna Mukherjee, Preity Pragnya Sahoo, Laxmi Narayan Tiwari, Basant Narain Singh, Rashmi Kumari, Anisha Kumari, Ankit Rai, Shashikant Ray
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引用次数: 0

Abstract

Cancer poses a serious threat to health globally, with millions diagnosed every year. According to Global Cancer Statistics 2024, about 20 million new cases were reported in 2022, and 9.7 million people worldwide died of this condition. Advanced therapies include combination of one or more treatment procedures, depending on the type, stage, and particular genetic constitution of the cancer, which may include surgery, radiotherapy, chemotherapy, immunotherapy, hormone therapy, targeted therapy, and stem cell transplant. Also, awareness about lifestyle changes, preventive measures and screening at early stages has reduced the incidence of the disease; still, there is a major failure in controlling the incidence of cancer because of its complex and multifaceted nature. With increasing interest in bacterial metabolites as possible novel and effective treatment options in cancer therapy, their main benefits include not only direct anticancer effects but also the modulation of the immune system and potential for targeted and combination therapies. They can therefore be used in combination with chemotherapy, radiotherapy, or immunotherapy to improve outcomes or reduce side effects. Furthermore, nanoparticle-based delivery systems have the potential to enhance the potency and safety of anticancer drugs by providing improved stability, targeted release, and controlled delivery.

Graphical abstract

利用细菌代谢物加强癌症化疗:揭示独特的治疗潜力
癌症对全球健康构成严重威胁,每年有数百万人确诊患癌。根据《2024 年全球癌症统计》,2022 年报告的新增病例约为 2 000 万例,全球有 970 万人死于癌症。晚期疗法包括一种或多种治疗程序的组合,取决于癌症的类型、阶段和特定的遗传体质,其中可能包括手术、放疗、化疗、免疫疗法、激素疗法、靶向疗法和干细胞移植。此外,人们对改变生活方式、预防措施和早期筛查的认识也降低了癌症的发病率;但由于癌症的复杂性和多面性,在控制癌症发病率方面仍然存在重大失误。随着人们对细菌代谢物作为癌症治疗中可能的新型有效治疗方案的兴趣与日俱增,它们的主要益处不仅包括直接抗癌作用,还包括调节免疫系统以及靶向治疗和联合治疗的潜力。因此,它们可与化疗、放疗或免疫疗法结合使用,以提高疗效或减少副作用。此外,以纳米粒子为基础的给药系统通过提高稳定性、靶向释放和控制给药,有可能增强抗癌药物的效力和安全性。
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来源期刊
Archives of Microbiology
Archives of Microbiology 生物-微生物学
CiteScore
4.90
自引率
3.60%
发文量
601
审稿时长
3 months
期刊介绍: Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.
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