D. A. Poletaeva, A. V. Smolina, V. N. Varfolomeev, N. N. Lashmanov, E. N. Klimanova, E. A. Khakina, O. A. Kraevaya, P. A. Troshin, I. I. Faingold
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引用次数: 0
Abstract
Fullerene–ruboxyl dyad was studied as a promising hybrid nanostructure for biomedical applications. It was shown that fullerene–ruboxyl dyad effectively interacts with the liposomal membrane in the region of the polar heads of phospholipids and has pronounced antiradical properties in vitro studies. Fullerene–ruboxyl dyad also affects the activity of membrane-bound mitochondrial enzymes, monoamine oxidases A and B, and cytochrome c oxidase, which could potentially lead to the support of normal mitochondrial functioning. It was established that the conjugation of daunoruboxil with fullerene significantly reduces acute toxicity compared to the original fullerene derivative; the dyad does not exhibit toxic properties at doses up to 1000 mg/kg. In addition, the possibility of using the fullerene–ruboxyl dyad for pharmacokinetic studies using the electron paramagnetic resonance (EPR) method is presented.
研究人员将富勒烯-鲁伯羰基二元化合物作为一种具有生物医学应用前景的混合纳米结构进行了研究。研究表明，富勒烯-红羰基二元化合物能有效地与磷脂极性头区域的脂质体膜相互作用，并在体外研究中具有明显的抗自由基特性。富勒烯-红羰基二元化合物还能影响与膜结合的线粒体酶、单胺氧化酶 A 和 B 以及细胞色素 c 氧化酶的活性，从而有可能支持线粒体的正常功能。研究证实，与原始富勒烯衍生物相比，达乌诺昔与富勒烯共轭可显著降低急性毒性；在剂量高达 1000 毫克/千克时，二者不会表现出毒性。此外，还介绍了利用电子顺磁共振（EPR）方法将富勒烯-鲁伯昔二元共轭物用于药代动力学研究的可能性。
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Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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