Influence of Gamma Radiation on the Stability and Properties of Poly(Lactide-Glycolide) Nanoparticles in an Aqueous Dispersion

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2024-10-29 DOI:10.1134/S2635167624601086

A. I. Kulebyakina, I. A. Ivanov, K. T. Kalinin, P. V. Dmitryakov, A. N. Veleshko, K. V. Kondratyev, E. N. Poznyrev, T. E. Grigoriev, R. A. Aliev, S. N. Chvalun

引用次数: 0

Abstract

Studying the effect of radiation on the stability and properties of nanoparticles is an important step in the development of drug delivery systems and radiopharmaceuticals. This work investigates the effect of gamma radiation with a total dose from 3 to 127 kGy on aqueous dispersions of poly(lactide-co-glycolic acid) (PLGA) nanoparticles stabilized with polyvinyl alcohol (PVA). It is found that after irradiation with doses up to 20 kGy, destruction occurs rapidly, and then it slows down. At the same time, the glass transition temperature of the PLGA core is practically unchanged and remains in the range of 37–38°C. The hydrodynamic diameter of the particles decreases due to the destruction of the PVA polymer chains. The hydrolysis of the irradiated and non-irradiated particles occurs at similar rates, which is probably explained by the glassy state of the core.

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伽马辐射对水分散体中聚（乳糖-乙二醇）纳米粒子稳定性和特性的影响

研究辐射对纳米颗粒稳定性和特性的影响是开发药物输送系统和放射性药物的重要步骤。这项工作研究了总剂量为 3 至 127 kGy 的伽马辐射对用聚乙烯醇（PVA）稳定的聚（乳酸-共羟基乙酸）（PLGA）纳米粒子水分散体的影响。研究发现，在 20 kGy 以下剂量的辐照后，破坏迅速发生，然后减慢。与此同时，PLGA 内核的玻璃化转变温度几乎没有变化，保持在 37-38°C 之间。由于 PVA 聚合物链的破坏，颗粒的流体力学直径减小。辐照颗粒和非辐照颗粒的水解速度相似，这可能与核心的玻璃态有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.