Nanoparticles formation through photopolymerization of pyrrole with lecithin for enhanced mitochondrial activation via NIR-photothermal mild-hyperthermia

IF 2.6 4区化学 Q3 POLYMER SCIENCE

Journal of Polymer Research Pub Date : 2024-10-30 DOI:10.1007/s10965-024-04174-2

Chih-Kuang Chen, Andrew E.-Y. Chuang

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引用次数: 0

Abstract

The development of biocompatible nanoparticles (NPs) with effective photothermal properties is essential for advancing biomedical applications. This study investigates the synthesis and characterization of lecithin-polypyrrole nanoparticles (LEC-PPy NPs) formed through near-infrared (NIR) irradiation. LEC-PPy NPs were prepared by mixing lecithin with varying concentrations of pyrrole monomer, followed by NIR irradiation to induce potential polymerization. Characterization techniques, including Dynamic Light Scattering (DLS), Zeta Potential Analysis, FTIR, XRD, and TEM, were employed. The prepared NPs demonstrated a photothermal response, reaching temperatures above around 43 °C under NIR exposure while exhibiting cell viability and minimal hemolysis. The biochemical tests of the cellular membrane potential and AHR further validate their biological response. This study highlights the implication of NIR-induced polymerization in producing biocompatible LEC-PPy NPs, which show potential for various biomedical applications. Further optimization and in vivo validation are necessary to realize their clinical potential.

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吡咯与卵磷脂光聚合形成纳米颗粒，通过近红外光热温和超温激活线粒体

开发具有有效光热特性的生物相容性纳米粒子（NPs）对于推进生物医学应用至关重要。本研究探讨了通过近红外（NIR）辐照形成的卵磷脂-聚吡咯纳米粒子（LEC-PPy NPs）的合成和表征。制备 LEC-PPy NPs 的方法是将卵磷脂与不同浓度的吡咯单体混合，然后用近红外照射诱导潜在聚合。表征技术包括动态光散射（DLS）、Zeta 电位分析、傅立叶变换红外光谱、XRD 和 TEM。制备的 NPs 具有光热响应，在近红外照射下温度可达到 43 ℃ 以上，同时细胞存活率高，溶血现象极少。细胞膜电位和 AHR 的生化测试进一步验证了它们的生物响应。这项研究强调了近红外诱导聚合在生产生物相容性 LEC-PPy NPs 中的意义，LEC-PPy NPs 具有各种生物医学应用的潜力。要实现其临床应用潜力，还需要进一步优化和体内验证。

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来源期刊

Journal of Polymer Research 化学-高分子科学

CiteScore

4.70

自引率

7.10%

发文量

472

审稿时长

3.6 months

期刊介绍： Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.