{"title":"Therapeutic and responsive release mechanisms of polymer drug conjugates with diverse polymer skeletons","authors":"Wenjie Zhao, Kaichuang Sun, Jianqin Yan, Yong Sun, Dengshuai Wei","doi":"10.1016/j.nantod.2024.102526","DOIUrl":null,"url":null,"abstract":"<div><div>Polymer-drug conjugates (PDCs) have emerged as an advanced strategy in the drug delivery. The conjugation of therapeutic or diagnostic agents to polymers, such as polyurethane, polyester, RAFT-based polymers, and poly(amino acid)s, presents several advantages, including enhanced drug solubilization, controlled release, reduced immunogenicity, prolonged circulation, improved safety, and increased efficacy. Recent research has focused extensively on engineering efficient tumor microenvironment (TME)-responsive PDCs, leading to significant advancements in cancer diagnosis and therapy. This review discusses the rational design, mechanisms of responsive release, physicochemical properties, and recent developments in various polymer systems for PDCs. We categorize PDCs based on their skeletal designs, including polyurethane, polyester, RAFT polymers, and polyamino acids. Additionally, we emphasize the TME responsiveness of PDCs, highlighting its critical role in various tumor therapies. Finally, we address the current challenges faced by PDCs and offer perspectives for future research, providing insights into the utility and potential of this technology. We hope this review serves as a valuable resource for the selection and optimization of PDCs, facilitating their future applications in cancer therapeutics.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102526"},"PeriodicalIF":13.2000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224003827","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Polymer-drug conjugates (PDCs) have emerged as an advanced strategy in the drug delivery. The conjugation of therapeutic or diagnostic agents to polymers, such as polyurethane, polyester, RAFT-based polymers, and poly(amino acid)s, presents several advantages, including enhanced drug solubilization, controlled release, reduced immunogenicity, prolonged circulation, improved safety, and increased efficacy. Recent research has focused extensively on engineering efficient tumor microenvironment (TME)-responsive PDCs, leading to significant advancements in cancer diagnosis and therapy. This review discusses the rational design, mechanisms of responsive release, physicochemical properties, and recent developments in various polymer systems for PDCs. We categorize PDCs based on their skeletal designs, including polyurethane, polyester, RAFT polymers, and polyamino acids. Additionally, we emphasize the TME responsiveness of PDCs, highlighting its critical role in various tumor therapies. Finally, we address the current challenges faced by PDCs and offer perspectives for future research, providing insights into the utility and potential of this technology. We hope this review serves as a valuable resource for the selection and optimization of PDCs, facilitating their future applications in cancer therapeutics.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.