Human chorionic gonadotropin of pituitary origin in Chinese postmenopausal women: A single-center retrospective study

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-10-29 DOI:10.1016/j.tjog.2024.06.011

Yonghong Tian , Long Zhang , Jingping Li , Huijuan Gao , Yimin Zhu

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Abstract

Objective

We analyze the characteristics and related factors of human chorionic gonadotropin (hCG) of pituitary origin to establish the reference interval to resolve clinical confusion and avoid harmful therapy to Chinese postmenopausal women with “positive” hCG.

Materials and methods

This retrospective cohort study identified individuals who underwent hCG measurements at an academic hospital. Three gonadotropins (hCG, follicle stimulating hormone (FSH), and luteinizing hormone (LH)) was drawn from medical records. The age-stratified analyses were performed first. Then the correlations of hCG and FSH, LH as well as age were analysed. Finally, characteristics and associations of hCG, LH, and FSH were evaluated to identify pituitary hCG in postmenopausal women in clinical settings.

Results

In total, 9796 cases from 11172 records met inclusion criteria and contributed 9796 hCG, 7541 FSH, and 7536 LH values. The upper reference interval for our cohorts was 5.3 IU/L. HCG, FSH, and LH concentration had no significant correlations with age. HCG moderately correlated with FSH (r = 0.47) and LH level (r = 0.53). However, it was FSH but not LH that manifested good clinical applicability.

Conclusion

The prevalence of hCG≥5.0 IU/L and 5.3 IU/L in women ≥55 years is 2.8% and 2.3% in the study population from China. The level of hCG 5.3 IU/L was suggested to be the positive threshold for postmenopausal women. FSH≥40IU/L helps to distinguish the pituitary source of hCG in postmenopausal women whose serum hCG concentrations were between 5.3 and 16 IU/L.

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中国绝经后妇女垂体来源的人绒毛膜促性腺激素：单中心回顾性研究

目的我们分析了垂体源性人绒毛膜促性腺激素（hCG）的特征和相关因素，以确定参考区间，从而解决临床上的困惑，避免对中国绝经后妇女的hCG "阳性 "治疗造成伤害。从病历中提取了三种促性腺激素（hCG、促卵泡激素（FSH）和促黄体生成素（LH））。首先进行了年龄分层分析。然后分析了 hCG 与 FSH、LH 以及年龄的相关性。最后，评估了 hCG、LH 和 FSH 的特征和相关性，以确定临床环境中绝经后妇女的垂体 hCG。我们队列的参考区间上限为 5.3 IU/L。HCG、FSH 和 LH 浓度与年龄无显著相关性。HCG 与 FSH（r = 0.47）和 LH 水平（r = 0.53）呈中度相关。结论在中国的研究人群中，hCG≥5.0 IU/L和5.3 IU/L在55岁以上女性中的发病率分别为2.8%和2.3%。建议将 hCG 5.3 IU/L 水平作为绝经后妇女的阳性阈值。FSH≥40IU/L有助于区分血清hCG浓度在5.3至16 IU/L之间的绝经后妇女hCG的垂体来源。

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来源期刊

Taiwanese Journal of Obstetrics & Gynecology OBSTETRICS & GYNECOLOGY-

CiteScore

3.60

自引率

23.80%

发文量

207

审稿时长

4-8 weeks

期刊介绍： Taiwanese Journal of Obstetrics and Gynecology is a peer-reviewed journal and open access publishing editorials, reviews, original articles, short communications, case reports, research letters, correspondence and letters to the editor in the field of obstetrics and gynecology. The aims of the journal are to: 1.Publish cutting-edge, innovative and topical research that addresses screening, diagnosis, management and care in women''s health 2.Deliver evidence-based information 3.Promote the sharing of clinical experience 4.Address women-related health promotion The journal provides comprehensive coverage of topics in obstetrics & gynecology and women''s health including maternal-fetal medicine, reproductive endocrinology/infertility, and gynecologic oncology. Taiwan Association of Obstetrics and Gynecology.