Exploring nitro-Tröger’s bases for ct-DNA and HSA sensing: An experimental and theoretical study

IF 4.1 3区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2024-10-11 DOI:10.1016/j.jphotochem.2024.116082

Eduam Oliveira Boeira , Victória Goulart Isoppo , Bruno Bercini de Araújo , Isadora Tisoco , Lilian Camargo da Luz , Otávio Augusto Chaves , Paulo Fernando Bruno Gonçalves , Bernardo Almeida Iglesias , Angélica Venturini Moro , Fabiano Severo Rodembusch

引用次数: 0

Abstract

In this study, we present Tröger’s base analogs synthesized through condensation between p-formaldehyde and methyl-nitro-anilines in good yields. Tröger’s bases exhibit absorption peaks around 350 nm attributed to allowed ππ* electronic transitions. The fluorescence emission at 380 nm showed no correlation with the position of the nitro group. Spectroscopic analyses employing UV–Vis absorption, steady-state fluorescence emission, and molecular docking calculations revealed that these Tröger’s bases interact effectively with ct-DNA and human serum albumin (HSA). These findings suggest that this class of compounds might serve as promising optical sensors for biomacromolecules.

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探索硝基特罗格碱基的ct-DNA和HSA传感：实验和理论研究

在本研究中，我们介绍了通过对甲醛和甲基硝基苯胺缩合合成的特罗格氏碱类似物，产量很高。特罗格氏碱在 350 nm 附近出现吸收峰，这归因于允许的 ππ* 电子转变。380 纳米波长处的荧光发射与硝基的位置无关。利用紫外可见吸收、稳态荧光发射和分子对接计算进行的光谱分析显示，这些特罗格氏碱能与ct-DNA 和人血清白蛋白（HSA）有效地相互作用。这些研究结果表明，这类化合物有可能成为有前途的生物大分子光学传感器。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Photochemistry and Photobiology A-chemistry 化学-物理化学

CiteScore

7.90

自引率

7.00%

发文量

580

审稿时长

48 days

期刊介绍： JPPA publishes the results of fundamental studies on all aspects of chemical phenomena induced by interactions between light and molecules/matter of all kinds. All systems capable of being described at the molecular or integrated multimolecular level are appropriate for the journal. This includes all molecular chemical species as well as biomolecular, supramolecular, polymer and other macromolecular systems, as well as solid state photochemistry. In addition, the journal publishes studies of semiconductor and other photoactive organic and inorganic materials, photocatalysis (organic, inorganic, supramolecular and superconductor). The scope includes condensed and gas phase photochemistry, as well as synchrotron radiation chemistry. A broad range of processes and techniques in photochemistry are covered such as light induced energy, electron and proton transfer; nonlinear photochemical behavior; mechanistic investigation of photochemical reactions and identification of the products of photochemical reactions; quantum yield determinations and measurements of rate constants for primary and secondary photochemical processes; steady-state and time-resolved emission, ultrafast spectroscopic methods, single molecule spectroscopy, time resolved X-ray diffraction, luminescence microscopy, and scattering spectroscopy applied to photochemistry. Papers in emerging and applied areas such as luminescent sensors, electroluminescence, solar energy conversion, atmospheric photochemistry, environmental remediation, and related photocatalytic chemistry are also welcome.