Preparation of cysteine-functionalized graphene quantum dots – Zinc phthalocyanines supramolecular hybrid system and their sono-photochemical studies

IF 4.1 3区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2024-10-24 DOI:10.1016/j.jphotochem.2024.116108

Gökçe Gökçil , Göknur Yaşa Atmaca , Pınar Şen , Fikrettin Şahin , Ali Erdoğmuş

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Abstract

Current PDT agents often suffer from low singlet oxygen quantum yields, photobleaching, and poor biocompatibility. To address these issues, we propose novel PDT agents that combine the synthesized phthalocyanines with cysteine-functionalized graphene quantum dots (cys-GQDs) for the first time. This combination aims to enhance singlet oxygen production and improve solubility in biological media. In this way, new zinc phthalocyanines with halogen substituents were synthesized for potential use in photodynamic therapy (PDT). Specifically, 2-Bromo-4-methylphenol zinc (II) phthalocyanine (2a) and 2-chloro-4-methylphenol zinc(II) phthalocyanine (2b) and their graphene quantum dots derivatives were synthesized and characterized. The photochemical, sonochemical, and sono-photochemical properties of these compounds were analyzed, focusing on their efficiency in singlet oxygen production. Our studies of the 2a@cys-GQDs and 2b@cys-GQDs conjugates demonstrated higher singlet oxygen yields, suggesting their enhanced potential for clinical applications.

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半胱氨酸功能化石墨烯量子点-酞菁锌超分子杂化体系的制备及其声光化学研究

目前的光透射疗法制剂往往存在单线态氧量子产率低、光漂白和生物相容性差等问题。为了解决这些问题，我们首次提出了将合成的酞菁与半胱氨酸功能化石墨烯量子点（cys-GQDs）相结合的新型光导放疗药物。这种组合旨在提高单线态氧的产生，并改善其在生物介质中的溶解度。通过这种方法，我们合成了具有卤素取代基的新型锌酞菁，有望用于光动力疗法（PDT）。具体而言，合成并表征了 2-溴-4-甲基苯酚锌（II）酞菁（2a）和 2-氯-4-甲基苯酚锌（II）酞菁（2b）及其石墨烯量子点衍生物。我们分析了这些化合物的光化学、声化学和声光化学特性，重点研究了它们产生单线态氧的效率。我们对 2a@cys-GQDs 和 2b@cys-GQDs 共轭物的研究表明，它们具有更高的单线态氧产率，这表明它们具有更高的临床应用潜力。

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来源期刊

Journal of Photochemistry and Photobiology A-chemistry 化学-物理化学

CiteScore

7.90

自引率

7.00%

发文量

580

审稿时长

48 days

期刊介绍： JPPA publishes the results of fundamental studies on all aspects of chemical phenomena induced by interactions between light and molecules/matter of all kinds. All systems capable of being described at the molecular or integrated multimolecular level are appropriate for the journal. This includes all molecular chemical species as well as biomolecular, supramolecular, polymer and other macromolecular systems, as well as solid state photochemistry. In addition, the journal publishes studies of semiconductor and other photoactive organic and inorganic materials, photocatalysis (organic, inorganic, supramolecular and superconductor). The scope includes condensed and gas phase photochemistry, as well as synchrotron radiation chemistry. A broad range of processes and techniques in photochemistry are covered such as light induced energy, electron and proton transfer; nonlinear photochemical behavior; mechanistic investigation of photochemical reactions and identification of the products of photochemical reactions; quantum yield determinations and measurements of rate constants for primary and secondary photochemical processes; steady-state and time-resolved emission, ultrafast spectroscopic methods, single molecule spectroscopy, time resolved X-ray diffraction, luminescence microscopy, and scattering spectroscopy applied to photochemistry. Papers in emerging and applied areas such as luminescent sensors, electroluminescence, solar energy conversion, atmospheric photochemistry, environmental remediation, and related photocatalytic chemistry are also welcome.