Preclinical evidence for the anxiolytic- and antidepressant-like effects of citicoline and imipramine in the sciatic nerve-ligated mice

IF 2 Q3 NEUROSCIENCES
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引用次数: 0

Abstract

Background

Neuropathic pain is a usual condition followed by nerve injury. Experimental neuropathy is linked with delayed behavioral variations correlated to anxiety and depression behaviors. Imipramine is a tricyclic antidepressant that can diminish anxiety- and depressive-like behaviors. Also, citicoline as a dietary supplement has antidepressant and anxiolytic effects.

Methods

We sought to investigate citicoline's effect on anxiety-like (by elevated plus-maze (EPM)) and depression-like (by tail suspension test (TST)) responses as well as its potential to increase imipramine antidepressant properties in nerve-ligated mice.

Results

The results showed that induction of neuropathic pain through sciatic nerve ligation caused anxious- and depressant-like behaviors in male mice. On the other hand, intraperitoneal (i.p.) injections of moderate (50 mg/kg) and high (100 mg/kg) doses of citicoline and high dose of imipramine (5 mg/kg) significantly reduced anxiety- and depression-like behaviors induced by sciatic nerve ligation in male mice. Additionally, a low (25 mg/kg) dose of citicoline potentiated the anxiolytic- and antidepressant-like effects of different doses of imipramine when they co-injected in nerve-ligated mice. Isobolographic analysis indicated an additive effect of imipramine and citicoline on the occurrence of anxiolytic- and antidepressant-like behaviors in nerve-ligated mice. Our results showed that citicoline alone reduces anxiety- and depression-like behaviors. Furthermore, when co-administered with imipramine, citicoline potentiates imipramine effects.

Conclusions

Injection of citicoline (as a dietary supplement) along with imipramine improved the effectiveness of imipramine for the management of anxiety- and depressive-like responses in nerve-ligated mice.
柠檬胆碱和丙咪嗪对坐骨神经结扎小鼠抗焦虑和抗抑郁作用的临床前证据
背景神经病理性疼痛是神经损伤后的一种常见症状。实验性神经病变与焦虑和抑郁行为相关的延迟行为变化有关。丙咪嗪是一种三环类抗抑郁药,可减轻焦虑和抑郁样行为。方法我们试图研究柠檬胆碱对神经结扎小鼠焦虑样(通过高架迷宫(EPM))和抑郁样(通过尾悬吊试验(TST))反应的影响,以及其增加丙咪嗪抗抑郁特性的潜力。结果结果显示,通过坐骨神经结扎诱导神经性疼痛会导致雄性小鼠出现焦虑和抑郁样行为。另一方面,腹腔注射中等剂量(50 毫克/千克)和高剂量(100 毫克/千克)的柠檬胆碱以及高剂量的丙咪嗪(5 毫克/千克)可显著减少坐骨神经结扎诱导的雄性小鼠的焦虑和抑郁行为。此外,低剂量(25 毫克/千克)的柠檬胆碱与不同剂量的丙咪嗪同时注射到神经结扎小鼠体内,可增强丙咪嗪的抗焦虑和抗抑郁作用。等值线分析表明,咪唑帕明和柠檬胆碱对神经结扎小鼠抗焦虑和抗抑郁行为的发生具有叠加效应。我们的研究结果表明,单独使用柠檬胆碱可减少焦虑和抑郁样行为。结论在注射丙咪嗪的同时注射柠檬胆碱(作为一种膳食补充剂),可提高丙咪嗪治疗神经绑定小鼠焦虑和抑郁样反应的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
IBRO Neuroscience Reports
IBRO Neuroscience Reports Neuroscience-Neuroscience (all)
CiteScore
2.80
自引率
0.00%
发文量
99
审稿时长
14 weeks
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