Quetiapine-induced peripheral oedema: A case report and review of the literature

Abstract

Quetiapine is an atypical antipsychotic and is commonly prescribed in the treatment of psychiatric conditions. Quetiapine has been associated with peripheral oedema but it is considered a rare side effect. Cases however suggest it may occur more frequently than reported in clinical trials. The exact mechanism of quetiapine-induced oedema remains unclear. We report the first documented case in Africa of quetiapine-induced oedema. We also do a brief review of other case reports related to the same side effect. We suggest particular caution when prescribing in the elderly and patients on concomitant valproate therapy, with close monitoring of physical condition and cardiovascular state. Peripheral oedema is an important side effect that may influence treatment adherence and quality of life. By having an increased awareness of this problematic adverse effect of quetiapine, one can avoid unnecessary investigations as well as relapses, which may have a particularly profound impact on resource limited settings and low-to-middle income countries.