Study on the effect of the mixing method on particulate matter in compounded medication of insoluble β-lactam antibiotics: Simulation of biomedical heat transfer mechanism

IF 5.1 3区工程技术 Q2 ENERGY & FUELS

Thermal Science and Engineering Progress Pub Date : 2024-10-01 DOI:10.1016/j.tsep.2024.102982

Li Guochun , Xu Hong , Li Sulian , Deng Shuxia , Deng Gulin , Huang Xinwu

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引用次数: 0

Abstract

The combination of insoluble β-lactam antibiotics has been widely used in clinical therapy, but its release in vivo and bioavailability remain challenges. This study aims to simulate the mechanism of biomedical heat transfer and analyze the influence of particulate matter in the combination of insoluble β-lactam antibiotics, so as to improve the therapeutic effectiveness of the drugs and optimize the clinical medication regimen. A mixed method was used to study the particulate matter of insoluble β-lactam antibiotics. In vitro simulation systems, combined with computational fluid dynamics (CFD) and heat conduction models, were used to evaluate drug release behavior in organisms. The physicochemical properties of the particles were determined and their heat transfer efficiency under different biomedical conditions was evaluated. The results showed that different types of particulate matter had significant effects on the release rate and bioavailability of β-lactam antibiotics. Simulations show that the optimized particle structure can significantly increase the local concentration of the drug and thus enhance the antibacterial effect under specific conditions of biomedical heat transfer. Through the simulation of the biomedical heat transfer mechanism of the mixed method, we can better understand the behavior of particles in the compound administration of insoluble β-lactam antibiotics, and explore the personalized medication strategy based on this mechanism.

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不溶性β-内酰胺类抗生素复方制剂中混合方法对微粒物质影响的研究生物医学传热机制模拟

不溶性β-内酰胺类抗生素复方制剂已广泛应用于临床治疗，但其体内释放和生物利用度仍是难题。本研究旨在模拟生物医学传热机理，分析颗粒物对难溶性β-内酰胺类抗生素复方制剂的影响，从而提高药物疗效，优化临床用药方案。本研究采用混合法研究不溶性β-内酰胺类抗生素的微粒物质。体外模拟系统与计算流体动力学（CFD）和热传导模型相结合，用于评估药物在生物体内的释放行为。确定了颗粒的物理化学特性，并评估了它们在不同生物医学条件下的热传导效率。结果表明，不同类型的微粒物质对β-内酰胺类抗生素的释放速率和生物利用率有显著影响。模拟结果表明，在特定的生物医学传热条件下，优化的颗粒结构能显著提高药物的局部浓度，从而增强抗菌效果。通过对混合法生物医学传热机理的模拟，我们可以更好地理解颗粒在不溶性β-内酰胺类抗生素复合给药中的行为，并在此机理基础上探索个性化用药策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thermal Science and Engineering Progress Chemical Engineering-Fluid Flow and Transfer Processes

CiteScore

7.20

自引率

10.40%

发文量

327

审稿时长

41 days

期刊介绍： Thermal Science and Engineering Progress (TSEP) publishes original, high-quality research articles that span activities ranging from fundamental scientific research and discussion of the more controversial thermodynamic theories, to developments in thermal engineering that are in many instances examples of the way scientists and engineers are addressing the challenges facing a growing population – smart cities and global warming – maximising thermodynamic efficiencies and minimising all heat losses. It is intended that these will be of current relevance and interest to industry, academia and other practitioners. It is evident that many specialised journals in thermal and, to some extent, in fluid disciplines tend to focus on topics that can be classified as fundamental in nature, or are ‘applied’ and near-market. Thermal Science and Engineering Progress will bridge the gap between these two areas, allowing authors to make an easy choice, should they or a journal editor feel that their papers are ‘out of scope’ when considering other journals. The range of topics covered by Thermal Science and Engineering Progress addresses the rapid rate of development being made in thermal transfer processes as they affect traditional fields, and important growth in the topical research areas of aerospace, thermal biological and medical systems, electronics and nano-technologies, renewable energy systems, food production (including agriculture), and the need to minimise man-made thermal impacts on climate change. Review articles on appropriate topics for TSEP are encouraged, although until TSEP is fully established, these will be limited in number. Before submitting such articles, please contact one of the Editors, or a member of the Editorial Advisory Board with an outline of your proposal and your expertise in the area of your review.