Advancing plastics bio-upcycling with photosynthetic microorganisms using bioengineering and bioconversion strategies

IF 4.6 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Hazlam Shamin Ahmad Shaberi , Hamidun Bunawan , Sean Craig , Samantha J. Bryan , Ahmad Bazli Ramzi
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Abstract

Biotechnological interventions have been increasingly adopted for addressing the persistence and recalcitrance of fossil fuel-derived plastic waste. Bioremediation through microbial and enzymatic degradation offers promising solutions, yet economic and scalability challenges persist, especially for addressing plastic waste accumulation in aquatic ecosystems. Despite recent advancements in plastic bioconversion and bio-upcycling using recombinant enzymes and microbes, current genetic and biological engineering platforms mainly employed heterotrophic chassis such as Escherichia coli and Pseudomonas putida, that are not suitable for direct cultivation using wastewater sources. Photosynthetic microorganisms like cyanobacteria and microalgae offer a sustainable alternative to the heterotrophic counterparts, in not only converting wastewater and CO2 as carbon and energy sources but also bring about carbon-neutral bioconversion potentials. Therefore, this review explores bioengineering strategies required to develop and harness the capabilities of cyanobacteria and microalgae for plastic biomineralisation. Pathway engineering in selected chassis is highlighted by detailing the metabolic pathways involved in plastic degradation where the application of growth-coupled genome editing and advanced biotechnological tools is further discussed. By integrating biofoundry-driven bioengineering strategies with growth-coupled selection, microalgal strain development can be accelerated towards achieving high substrate-to-product yields thus promoting carbon-neutral biorefinery and plastic bioconversion approaches.

Abstract Image

采用生物工程和生物转化战略,利用光合微生物推进塑料的生物升级再循环
为解决化石燃料衍生塑料废物的持久性和顽固性问题,越来越多地采用了生物技术干预措施。通过微生物和酶降解进行生物修复提供了前景广阔的解决方案,但经济性和可扩展性方面的挑战依然存在,尤其是在解决塑料废物在水生生态系统中的积累问题方面。尽管最近在利用重组酶和微生物进行塑料生物转化和生物升级再循环方面取得了进展,但目前的基因和生物工程平台主要采用大肠杆菌和假单胞菌等异养基质,不适合利用废水源直接培养。蓝藻和微藻等光合微生物为异养微生物提供了一种可持续的替代品,不仅能将废水和二氧化碳转化为碳和能源,还能带来碳中和的生物转化潜力。因此,本综述探讨了开发和利用蓝藻和微藻的能力进行塑料生物矿化所需的生物工程策略。通过详细介绍塑料降解所涉及的代谢途径,重点介绍了所选底盘中的途径工程,并进一步讨论了生长耦合基因组编辑和先进生物技术工具的应用。通过将生物铸造驱动的生物工程战略与生长耦合选择相结合,可以加速微藻菌株的开发,实现从基质到产品的高产,从而促进碳中和生物炼制和塑料生物转化方法的发展。
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来源期刊
Algal Research-Biomass Biofuels and Bioproducts
Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
9.40
自引率
7.80%
发文量
332
期刊介绍: Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment
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