An entry to spiro-fused sultams via electrochemical brominative ipso-annulation of N-aryl alkynyl sulphonamides

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-22 DOI:10.1016/j.tetlet.2024.155330

Chada Raji Reddy , Maramoni Shivudu , Anjali Rathaur

引用次数: 0

Abstract

Synthesis of cyclohexadienone spiro-fused sultams is established through electrochemical brominative intramolecular ipso-annulation of N-aryl alkynyl sulphonamides. A range of aryl/heteroarylated-alkynyl sulphonamides are suitable under external oxidant-free electrochemical conditions. Lithium bromide is used as bromine source in this domino bromination/ipso-cyclization, leading to the corresponding bromo spiro-sultams in good yields.

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通过 N-芳基炔基磺酰胺的电化学溴化异烷基化反应进入螺融舒坦类化合物领域

通过对 N-芳基炔基磺酰胺进行电化学溴化分子内异annulation，合成了环己二烯酮螺融舒坦。在外部无氧化剂的电化学条件下，一系列芳基/异芳基炔基磺酰胺均适用。在这种多米诺溴化/异环化反应中，溴化锂被用作溴源，从而以良好的收率得到相应的溴代螺-苏丹。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

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