Relationship between hearing loss and Glasgow prognostic score in patients with cancer

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY

Auris Nasus Larynx Pub Date : 2024-10-26 DOI:10.1016/j.anl.2024.10.009

Shin Matsumoto , Yuki Hirose , Ryota Ishii , Masahiro Nakayama , Kazuki Takahashi , Kento Sasaki , Keitaro Fujii , Keiji Tabuchi

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引用次数: 0

Abstract

Objective

Oxidative stress damages cochlear hair cells in vitro. However, the effect of systemic inflammation on hearing loss remains unclear. Growing evidence suggests that malnutrition influences the development of hearing loss. In this study, we aimed to investigate the influence of the Glasgow prognostic score (GPS), which is calculated based on systemic inflammatory responses and malnutrition, on auditory threshold increases in patients with cancer.

Methods

This single-center retrospective cohort study included patients with cancer who underwent standard pure-tone audiometry (PTA) between November 2014 and May 2023. Patients with complete data in their electronic medical records within 90 days before undergoing standard PTA were included. Multivariate analysis was performed using auditory threshold as the response variable. Covariates, including GPS, were obtained from blood data and physical data before standard PTA. The GPS was classified into three levels based on serum albumin and C-reactive protein levels.

Results

Standard PTA was performed 14,868 times in 5,462 patients. Of these, 742 had cancer and 384 met the inclusion criteria. Multivariate analysis revealed that older age, creatinine clearance <60 mL/min, and high GPS significantly increased the auditory threshold at frequencies of 500–8,000 Hz. A history of platinum drug use and male sex increased the auditory threshold at frequencies >4,000 and >2,000 Hz, respectively.

Conclusion

The GPS was independently associated with elevated standard PTA thresholds in patients with cancer. These results suggest an association between malnutrition/chronic inflammation and hearing loss and provide new information for planning clinical research on hearing loss prevention.

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癌症患者听力损失与格拉斯哥预后评分之间的关系

目的体外氧化应激会损伤耳蜗毛细胞。然而，全身性炎症对听力损失的影响仍不清楚。越来越多的证据表明，营养不良会影响听力损失的发展。在这项研究中，我们旨在调查格拉斯哥预后评分（GPS）对癌症患者听觉阈值增加的影响，格拉斯哥预后评分是根据全身炎症反应和营养不良情况计算得出的。方法这项单中心回顾性队列研究纳入了2014年11月至2023年5月期间接受标准纯音测听（PTA）的癌症患者。研究纳入了接受标准纯音测听前 90 天内电子病历中数据完整的患者。使用听阈作为响应变量进行多变量分析。包括 GPS 在内的协变量均来自标准 PTA 前的血液数据和身体数据。根据血清白蛋白和 C 反应蛋白水平，GPS 被分为三个等级。其中 742 人患有癌症，384 人符合纳入标准。多变量分析显示，年龄较大、肌酐清除率<60 mL/min和高 GPS 会显著增加 500-8000 Hz 频率下的听觉阈值。结论 GPS与癌症患者标准PTA阈值升高密切相关。这些结果表明营养不良/慢性炎症与听力损失之间存在关联，为规划预防听力损失的临床研究提供了新的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.