Senescence and Inflamm-Aging Are Associated With Endothelial Dysfunction in Men But Not Women With Atherosclerosis

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2024-10-01 DOI:10.1016/j.jacbts.2024.06.012

Pauline Mury PhD , Gael Cagnone PhD , Olina Dagher MD , Florian Wünnemann PhD , Guillaume Voghel MD, PhD , Melissa Beaudoin MSc , Mélanie Lambert PhD , Géraldine Miquel BSc , Pierre-Emmanuel Noly MD, PhD , Louis P. Perrault MD, PhD , Michel Carrier MD , Nathalie Thorin-Trescases PhD , Jean-Sébastien Joyal MD, PhD , Guillaume Lettre PhD , Eric Thorin PhD

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引用次数: 0

Abstract

Coronary artery disease (CAD) is more prevalent in men than in women, with endothelial dysfunction, prodromal to CAD, developing a decade earlier in middle-aged men. We investigated the molecular basis of this dimorphism ex vivo in arterial segments discarded during surgery of CAD patients. The results reveal a lower endothelial relaxant sensitivity in men, and a senescence-associated inflammaging transcriptomic signature in endothelial cells. In women, cellular metabolism and endothelial maintenance pathways are conserved. This suggests that senolytic therapies to reduce risk of cardiovascular events in women with CAD may not be as effective as in men.

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衰老和炎症老化与男性动脉粥样硬化患者的内皮功能障碍有关，但与女性无关

冠状动脉疾病（CAD）在男性中的发病率高于女性，而在中年男性中，冠状动脉疾病的前驱症状--内皮功能障碍会提前十年出现。我们在对 CAD 患者进行手术时丢弃的动脉切片中研究了体内这种二态性的分子基础。结果显示，男性内皮松弛剂敏感性较低，内皮细胞中存在衰老相关的炎症转录组特征。在女性中，细胞代谢和内皮维护途径是一致的。这表明，旨在降低女性冠心病患者心血管事件风险的衰老疗法可能不如男性有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.