Prevalence and measurement of post-exertional malaise in post-acute COVID-19 syndrome: A systematic review and meta-analysis

IF 4.1 2区医学 Q1 PSYCHIATRY

General hospital psychiatry Pub Date : 2024-10-20 DOI:10.1016/j.genhosppsych.2024.10.011

Yi An, Ziyu Guo, Jin Fan, Tingting Luo, Huimin Xu, Huiying Li, Xi Wu

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引用次数: 0

Abstract

Objective

Post-exertional malaise (PEM) is a common and debilitating symptom of post-acute COVID-19 syndrome (PACS), and it is also included in the core outcome set for PACS. Our aims are to determine the prevalence of PEM in patients with PACS, and to review the measurement tools utilized in studies assessing PEM among these patients.

Methods

A systematic literature search was conducted up to 29 February 2024 across four databases: PubMed, EMBASE, Web of Science, and Cochrane Library. Studies were included if they evaluated PACS individuals who had at least one persistent symptom, with the mean or median follow-up duration of at least 3 months after COVID-19 diagnosis or hospital discharge, and specially reported on PEM or any measurement tools utilized to assess PEM. Data extraction and quality assessment were performed independently by two authors.

Results

After screening 953 articles, 12 studies comprising 2665 patients were included in the meta-analysis, and 16 studies were included in the narrative review. The pooled prevalence of PEM among PACS patients at 3 months or more after COVID-19 diagnosis was 0.55 (95 % CI, 0.38, 0.71). Moreover, narrative review identified seven questionnaires used to assess PEM in PACS individuals, with the DePaul Symptom Questionnaire–Post Exertional Malaise (DSQ-PEM) being the most frequently utilized instrument.

Conclusion

Our findings indicate that over half of the PACS individuals experience PEM, and seven questionnaires have been identified for researchers to assess PEM. It is imperative to develop effective intervention strategies to treat and alleviate the burden of PEM.

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急性 COVID-19 后综合征中劳累后乏力的患病率和测量方法：系统回顾和荟萃分析

目的劳累后乏力（PEM）是急性 COVID-19 后综合征（PACS）的一种常见且使人衰弱的症状，也被列入 PACS 的核心结果集。我们的目的是确定 PACS 患者中 PEM 的患病率，并回顾评估这些患者 PEM 的研究中所使用的测量工具：PubMed、EMBASE、Web of Science 和 Cochrane Library。如果研究对至少有一种持续性症状的 PACS 患者进行了评估，且平均或中位随访时间至少为 COVID-19 诊断或出院后 3 个月，并对 PEM 或用于评估 PEM 的任何测量工具进行了专门报告，则纳入该研究。数据提取和质量评估由两位作者独立完成。结果在筛选了953篇文章后，有12项研究（共2665名患者）被纳入荟萃分析，16项研究被纳入叙述性综述。在 COVID-19 诊断后 3 个月或更长时间的 PACS 患者中，PEM 的汇总患病率为 0.55（95 % CI，0.38，0.71）。结论我们的研究结果表明，半数以上的 PACS 患者患有 PEM，研究人员已确定了七种用于评估 PEM 的问卷。当务之急是制定有效的干预策略，以治疗和减轻 PEM 的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General hospital psychiatry 医学-精神病学

CiteScore

9.60

自引率

2.90%

发文量

125

审稿时长

20 days

期刊介绍： General Hospital Psychiatry explores the many linkages among psychiatry, medicine, and primary care. In emphasizing a biopsychosocial approach to illness and health, the journal provides a forum for professionals with clinical, academic, and research interests in psychiatry''s role in the mainstream of medicine.