DNA and IQ: Big deal or much ado about nothing? – A meta-analysis

IF 3.3 2区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY

Intelligence Pub Date : 2024-10-19 DOI:10.1016/j.intell.2024.101871

Florence A.R. Oxley , Kirsty Wilding , Sophie von Stumm

{"title":"DNA and IQ: Big deal or much ado about nothing? – A meta-analysis","authors":"Florence A.R. Oxley , Kirsty Wilding , Sophie von Stumm","doi":"10.1016/j.intell.2024.101871","DOIUrl":null,"url":null,"abstract":"<div><div>Intelligence is polygenic, highly heritable, and predicts wide-ranging life outcomes. Here, we meta-analysed the predictive validity of polygenic scores for intelligence based on the largest available genome-wide association study (or <em>GWAS</em>; Savage et al., 2018) for tested, phenotypic intelligence to date. Across 32 estimates from 9 independent samples, which all came from WEIRD countries and were of European ancestry (N<sub>total</sub> = 452,864), our meta-analytic estimate for the association between polygenic and phenotypic intelligence was <em>ρ</em> <em>=</em> <em>0</em>.245 (<em>p</em> <em><</em> .001, 95 % CI = 0.184–0.307), an effect of medium size. The meta-analytic estimate varied across samples, studies, and phenotypic measures of intelligence, and even after accounting for these moderators, polygenic score predictions remained significantly heterogenous. Our findings support claims that polygenic predictions of intelligence benefit and advance research but their utility in other contexts is yet to be demonstrated.</div></div>","PeriodicalId":13862,"journal":{"name":"Intelligence","volume":"107 ","pages":"Article 101871"},"PeriodicalIF":3.3000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Intelligence","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0160289624000655","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Intelligence is polygenic, highly heritable, and predicts wide-ranging life outcomes. Here, we meta-analysed the predictive validity of polygenic scores for intelligence based on the largest available genome-wide association study (or GWAS; Savage et al., 2018) for tested, phenotypic intelligence to date. Across 32 estimates from 9 independent samples, which all came from WEIRD countries and were of European ancestry (N_total = 452,864), our meta-analytic estimate for the association between polygenic and phenotypic intelligence was ρ = 0.245 (p < .001, 95 % CI = 0.184–0.307), an effect of medium size. The meta-analytic estimate varied across samples, studies, and phenotypic measures of intelligence, and even after accounting for these moderators, polygenic score predictions remained significantly heterogenous. Our findings support claims that polygenic predictions of intelligence benefit and advance research but their utility in other contexts is yet to be demonstrated.

查看原文本刊更多论文

DNA 和智商：大事还是小事？- 荟萃分析

智力是多基因的，具有高度遗传性，并能预测各种生活结果。在此，我们基于迄今为止最大的全基因组关联研究（或称 GWAS；Savage 等人，2018 年），对智力多基因评分的预测有效性进行了荟萃分析。来自9个独立样本的32个估计值均来自WEIRD国家，且均为欧洲血统（Ntotal = 452 864），我们对多基因与表型智力之间关联的元分析估计值为ρ = 0.245（p < .001，95 % CI = 0.184-0.307），属于中等规模效应。荟萃分析的估计值因样本、研究和智力表型测量而异，即使考虑了这些调节因素，多基因得分预测仍存在显著差异。我们的研究结果支持了多基因智力预测有利于和推动研究的说法，但它们在其他情况下的效用还有待证明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Intelligence PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

5.80

自引率

13.30%

发文量

审稿时长

69 days

期刊介绍： This unique journal in psychology is devoted to publishing original research and theoretical studies and review papers that substantially contribute to the understanding of intelligence. It provides a new source of significant papers in psychometrics, tests and measurement, and all other empirical and theoretical studies in intelligence and mental retardation.