Delivery system for dexamethasone phosphate based on a Zn2+-crosslinked polyelectrolyte complex of diethylaminoethyl chitosan and chondroitin sulfate

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED
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Abstract

Hybrid nano- and microparticles based on metal ion crosslinked biopolymers are promising carriers for the development of drug delivery systems with improved biopharmaceutical properties. In this work, dexamethasone phosphate-containing particles based on chondroitin sulfate and chitosan or diethylaminoethyl chitosan additionally crosslinked with Zn2+ were prepared. Depending on the polycation/polyanion ratio in the system, anionic and cationic polyelectrolyte complexes (PECs) were obtained. The anionic Zn2+-containing and Zn2+-free PECs had sizes of 154 and 180 nm and ζ-potentials of −22.4 and −27.5 mV, respectively. The cationic Zn2+-containing and Zn2+-free PECs had sizes of 242 and 362 nm and ζ-potentials of 22.4 and 24.7 mV, respectively. The presence of Zn2+ in the system significantly prolonged the release of dexamethasone phosphate from the hybrid polyelectrolyte particle. The resulting release profiles of dexamethasone phosphate were in agreement with the Peppas-Sahlin kinetic model, which considers the combined effects of Fickian diffusion and polymer chain relaxation on the drug release rate. It was shown that the prolongation of drug release was mainly due to swelling and relaxation of the Zn2+ crosslinked polymers. The developed particles exhibited good mucoadhesive properties and pronounced anti-inflammatory activity, making them attractive candidates for biomedical applications.
基于二乙氨基乙基壳聚糖和硫酸软骨素的 Zn2+交联聚电解质复合物的地塞米松磷酸盐给药系统
基于金属离子交联生物聚合物的混合纳米颗粒和微颗粒是一种很有前景的载体,可用于开发具有更好生物制药特性的给药系统。在这项工作中,制备了基于硫酸软骨素和壳聚糖或二乙胺基乙基壳聚糖并与 Zn2+ 交联的含磷酸地塞米松颗粒。根据体系中的多阳离子/多阴离子比例,可获得阴离子和阳离子聚电解质复合物(PECs)。含 Zn2+ 的阴离子聚电解质复合物和不含 Zn2+ 的聚电解质复合物的尺寸分别为 154 nm 和 180 nm,ζ电位分别为 -22.4 mV 和 -27.5 mV。含 Zn2+ 的阳离子 PEC 和不含 Zn2+ 的 PEC 的尺寸分别为 242 纳米和 362 纳米,ζ电位分别为 22.4 毫伏和 24.7 毫伏。系统中 Zn2+ 的存在大大延长了地塞米松磷酸盐从混合聚电解质颗粒中的释放时间。由此得出的磷酸地塞米松释放曲线与 Peppas-Sahlin 动力学模型一致,该模型考虑了费克扩散和聚合物链松弛对药物释放速率的综合影响。研究表明,药物释放时间的延长主要是由于 Zn2+ 交联聚合物的溶胀和松弛。所开发的颗粒具有良好的粘附性和明显的抗炎活性,因此在生物医学应用中具有吸引力。
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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