Synthesis and biological evaluation of 1, 2, 3-triazole incorporated pyrrole derivatives as anticancer agents

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-10-15 DOI:10.1080/00397911.2024.2408605

Somaiah Nalla , S. Aravind , Sri Charitha Annam , K. V. Padmavathi , Tasqeeruddin Syed , Mannam Subbarao

引用次数: 0

Abstract

A new series of 1,2,3-triazole skeleton incorporated pyrrole derivatives (11a–j) were developed and their chemical structures were confirmed by analytical data. Further, the anticancer profile of these newly derived compounds 11a–j was assessed against four types of human cancer cell lines such as human breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by employing of the MTT method and was compared with etoposide used as a positive control. Most of the examined derivatives displayed moderate to good activity compared with the positive control. Among them, five compounds 11a, 11b, 11c, 11d, and 11e showed more potent activity. Particularly, compound 11a showed superior activity.

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作为抗癌剂的 1, 2, 3-三唑并吡咯衍生物的合成和生物学评价

我们开发了一系列新的 1,2,3- 三唑骨架结合吡咯衍生物（11a-j），并通过分析数据确认了它们的化学结构。此外，还采用 MTT 法评估了这些新衍生化合物 11a-j 对四种人类癌细胞系（如人类乳腺癌（MCF-7）、肺癌（A549）、结肠癌（Colo-205）和卵巢癌（A2780））的抗癌作用，并与作为阳性对照的依托泊苷进行了比较。与阳性对照相比，大多数受检衍生物显示出中等至良好的活性。其中，5 个化合物 11a、11b、11c、11d 和 11e 显示出更强的活性。特别是化合物 11a 显示出更强的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.