Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers (Adv. Mater. Interfaces 30/2024)

IF 4.3 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Interfaces Pub Date : 2024-10-23 DOI:10.1002/admi.202470073

Ana Mateos-Maroto, Meiyu Gai, Maximilian Brückner, Volker Mailänder, Svenja Morsbach, Katharina Landfester

引用次数: 0

Abstract

Protein Functionalization

Modification of proteins is often required for their use as targeting agents. However, chemical over-modification can lead to the loss of their native structure and thus affect their functionality. Based on NHS ester chemistry, in this article 2400472 by Katharina Landfester and co-workers, a minimal protein modification strategy including detailed characterization is developed, keeping the secondary structure intact and allowing their further attachment to nanocarriers via click chemistry.

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蛋白质的受控功能化策略可在与纳米载体结合时保持其结构完整性（Adv. Mater. Interfaces 30/2024）

蛋白质功能化通常需要对蛋白质进行修饰，才能将其用作靶向制剂。然而，过度的化学修饰会导致蛋白质失去原生结构，从而影响其功能。在 Katharina Landfester 及其合作者撰写的这篇 2400472 文章中，基于 NHS 酯化学，开发出了一种包括详细表征在内的最小蛋白质修饰策略，既能保持二级结构完好无损，又能通过点击化学将其进一步附着到纳米载体上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials Interfaces CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

8.40

自引率

5.60%

发文量

1174

审稿时长

1.3 months

期刊介绍： Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018. The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface. Advanced Materials Interfaces covers all topics in interface-related research: Oil / water separation, Applications of nanostructured materials, 2D materials and heterostructures, Surfaces and interfaces in organic electronic devices, Catalysis and membranes, Self-assembly and nanopatterned surfaces, Composite and coating materials, Biointerfaces for technical and medical applications. Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.