Electroreductive deoxygenative carboxylation of alkyl oxalates with CO2†

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-10-02 DOI:10.1039/D4GC03452J

Yong Yuan, Hangfei Jiang, Ya-Nan Zhang, Yuyan Tao, Xincong Liu and Congde Huo

引用次数: 0

Abstract

An electroreductive deoxygenative carboxylation of alkyl oxalates with CO₂ is demonstrated for the first time, which offers a general and scalable method for obtaining various carboxylic acids. This electrochemical method features a broad substrate scope and mild reaction conditions; various secondary benzyl alcohols and non-benzylic alcohols, primary benzyl alcohols and non-benzylic alcohols, and tertiary benzyl alcohols and non-benzylic alcohols can be converted into the corresponding carboxylic acids in good to excellent yields. Importantly, this electroreductive deoxygenative carboxylation reaction also offers a mild and straightforward route to access drug molecules, such as ibuprofen, (±) naproxen, fenoprofen, hexaprofen, and biprofen.

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烷基草酸盐与 CO2† 的电还原脱氧羧化反应

首次展示了烷基草酸盐与二氧化碳的电还原脱氧羧化反应，为获得各种羧酸提供了一种通用的、可扩展的方法。这种电化学方法具有底物范围广、反应条件温和的特点；各种仲苄基醇和非苄基醇、伯苄基醇和非苄基醇以及叔苄基醇和非苄基醇都能以良好到极佳的产率转化为相应的羧酸。重要的是，这种电还原脱氧羧化反应还为布洛芬、(±)萘普生、非诺洛芬、己洛芬和联洛芬等药物分子的获取提供了一条温和而直接的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.