Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps.

IF 1.7 4区 医学 Q4 BIOPHYSICS
Navideh Abbasnezhad, Farid Bakir
{"title":"Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps.","authors":"Navideh Abbasnezhad, Farid Bakir","doi":"10.1115/1.4067009","DOIUrl":null,"url":null,"abstract":"<p><p>Blood pumps, critical components in ventricular assist devices and extracorporeal membrane oxygenation systems, are primarily evaluated based on their ability to minimize blood damage through optimized design. Despite extensive research, the impact of impeller blade thickness and the proximity of rotating and stationary surfaces remains insufficiently explored. This study presents a comprehensive analysis, combining experimentally validated numerical simulations with an advanced Lagrangian approach, to compare the hemodynamic and hemolytic performance of three centrifugal pumps. These pumps share identical volutes but differ in impeller blade thickness. The selected operating point-a blood flow rate of 1 l/min and a pressure differential of 60 mm Hg-was chosen for its clinical relevance, particularly in pediatric applications. Computational fluid dynamics (CFD) simulations were employed to evaluate hemodynamic performance, while Lagrangian postprocessing was used to estimate the hemolysis index (HI) by tracing fluid particle trajectories. These analyses provided detailed insights into velocity, pressure, and shear stress (SS) distributions, with special attention given to critical regions near clearance gaps and solid boundaries. The results reveal a significant increase in hemolysis risk in these regions, especially as the size of opposing rotating and stationary surfaces increases. The pump with the thickest blades (pump 3) exhibited the poorest performance, with shear stress and hemolysis index negatively impacted by the increased blade thickness. Although specific to the pumps studied, these findings offer valuable guidance for the optimal design of blood pumps and suggest that the analytical approach could be applied to other sensitivity studies.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomechanical Engineering-Transactions of the Asme","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1115/1.4067009","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0

Abstract

Blood pumps, critical components in ventricular assist devices and extracorporeal membrane oxygenation systems, are primarily evaluated based on their ability to minimize blood damage through optimized design. Despite extensive research, the impact of impeller blade thickness and the proximity of rotating and stationary surfaces remains insufficiently explored. This study presents a comprehensive analysis, combining experimentally validated numerical simulations with an advanced Lagrangian approach, to compare the hemodynamic and hemolytic performance of three centrifugal pumps. These pumps share identical volutes but differ in impeller blade thickness. The selected operating point-a blood flow rate of 1 l/min and a pressure differential of 60 mm Hg-was chosen for its clinical relevance, particularly in pediatric applications. Computational fluid dynamics (CFD) simulations were employed to evaluate hemodynamic performance, while Lagrangian postprocessing was used to estimate the hemolysis index (HI) by tracing fluid particle trajectories. These analyses provided detailed insights into velocity, pressure, and shear stress (SS) distributions, with special attention given to critical regions near clearance gaps and solid boundaries. The results reveal a significant increase in hemolysis risk in these regions, especially as the size of opposing rotating and stationary surfaces increases. The pump with the thickest blades (pump 3) exhibited the poorest performance, with shear stress and hemolysis index negatively impacted by the increased blade thickness. Although specific to the pumps studied, these findings offer valuable guidance for the optimal design of blood pumps and suggest that the analytical approach could be applied to other sensitivity studies.

叶片厚度对血液动力学和溶血的影响:儿科离心血泵案例研究。
无论是作为植入式心室辅助装置,还是作为体外膜氧合,血泵都已变得非常流行。这些泵的质量是根据其几何和运行特性的优化选择来降低血液损伤风险的能力来评估的。由于缺乏对叶轮几何优化的重点研究,因此促成了这项研究。本研究通过计算和实验分析,比较了三种离心泵的溶血性能。为此,分别采用欧拉和拉格朗日方法进行血液动力学和血液相容性研究。根据儿科需求,这些泵在临床适用的压力-流量条件下工作:血流量为 1 升/分钟,压差为 60 毫米汞柱。这三种泵都使用相同的涡壳,但叶轮的叶片厚度不同。目的是研究表面积如何影响溶血的产生。以下两项任务均采用了硅模拟:第一,确定速度、压力和剪切应力的分布;第二,采用拉格朗日方法估算溶血指数。结果表明,流动通道和间隙表面对泵的血液相容性非常重要。不过,观察发现,叶片厚度对剪切应力或溶血指数的影响并不呈线性关系。此外,这项研究还为开发血液兼容性更强的血液泵的优化设计提供了信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.40
自引率
5.90%
发文量
169
审稿时长
4-8 weeks
期刊介绍: Artificial Organs and Prostheses; Bioinstrumentation and Measurements; Bioheat Transfer; Biomaterials; Biomechanics; Bioprocess Engineering; Cellular Mechanics; Design and Control of Biological Systems; Physiological Systems.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信