Exploring the prognostic value and potential therapeutic strategies of MS4A6A in glioblastoma: A comprehensive analysis of single-cell and multi-omics data

IF 5.3
Fangchao Wan, Yanling Li, Jianming Zhu, Dandan Yu, Hongjuan Liu, Bohong Hu
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引用次数: 0

Abstract

Glioblastoma (GBM) is a highly aggressive and treatment-resistant malignancy that poses a significant challenge in modern medicine. Despite advances in surgical resection, radiotherapy and chemotherapy, complete eradication of GBM remains elusive due to its diffuse invasion into the brain parenchyma and propensity for recurrence. The tumour microenvironment (TME), particularly macrophages, has emerged as a critical player in GBM progression, invasion and metastasis. In the immune microenvironment of glioma, MS4A6A exhibits unique expression characteristics in macrophages. This study aimed to investigate the potential role of MS4A6A, a gene associated with aging and neurodegenerative diseases, in GBM and its potential as a prognostic biomarker and therapeutic target.

Abstract Image

探索 MS4A6A 在胶质母细胞瘤中的预后价值和潜在治疗策略:单细胞和多组学数据的综合分析。
胶质母细胞瘤(GBM)是一种侵袭性极强、耐药性极强的恶性肿瘤,给现代医学带来了巨大挑战。尽管在手术切除、放疗和化疗方面取得了进展,但由于胶质母细胞瘤向脑实质的弥漫性侵袭和复发倾向,彻底根治胶质母细胞瘤仍然遥遥无期。肿瘤微环境(TME),尤其是巨噬细胞,已成为 GBM 进展、侵袭和转移的关键因素。在胶质瘤的免疫微环境中,MS4A6A在巨噬细胞中表现出独特的表达特征。MS4A6A 是一种与衰老和神经退行性疾病相关的基因,本研究旨在探讨 MS4A6A 在 GBM 中的潜在作用及其作为预后生物标志物和治疗靶点的潜力。
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来源期刊
CiteScore
11.50
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0.00%
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期刊介绍: The Journal of Cellular and Molecular Medicine serves as a bridge between physiology and cellular medicine, as well as molecular biology and molecular therapeutics. With a 20-year history, the journal adopts an interdisciplinary approach to showcase innovative discoveries. It publishes research aimed at advancing the collective understanding of the cellular and molecular mechanisms underlying diseases. The journal emphasizes translational studies that translate this knowledge into therapeutic strategies. Being fully open access, the journal is accessible to all readers.
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